Sponsor or institution
Clinical trials and research at Massachusetts Institute of Technology
As of November 12, 2026, Find a Trial lists 9 clinical trials run by Massachusetts Institute of Technology that are recruiting, in United States. By phase: Phase 2 (1), Phase 4 (1). There are also 383 NIH-funded research projects at this institution, with $262.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 9Clinical trials
- 383NIH research projects
- 1Country
Newest trials
All recruiting trials (9)
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Wearable exosuit to help people with knee osteoarthritis move more
This study tests a wearable exoskeleton (Dephy Exoboot) to see if it helps adults with knee osteoarthritis walk more and reduce pain.
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Powered ankle prosthesis with neural control and skin feedback for people with lower-leg amputation
A powered ankle prosthesis that uses neural signals and skin stimulation to help people with a transtibial amputation walk more naturally.
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40Hz light, sound, and touch stimulation to change brain activity in people with and without Alzheimer's disease.
This one-day visit will test whether non-invasive 40Hz light, sound, and touch stimulation can change brain activity, connectivity, and blood markers in cognitively normal adults and people with Alzheimer's disease.
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Neural-controlled powered knee and ankle for people with above-knee amputation.
We will test whether a neural-controlled powered knee or ankle prosthesis helps people with above-knee (transfemoral) amputation walk more naturally and stably in everyday situations.
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Outreach program to improve engagement in a wellness initiative for metabolic syndrome
This study is testing if a new way of inviting people to join a wellness program can help those with metabolic syndrome get better support for weight management and diabetes prevention.
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Using light and sound therapy to treat Alzheimer's disease
This study is testing whether a light and sound device can help people with mild Alzheimer's disease improve their memory and brain function over six months.
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Cannabidiol to reduce social anxiety symptoms
This will try a single dose of Epidiolex (cannabidiol) to see if it reduces anxiety during a standardized social stress test in adults with social anxiety disorder.
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Using light, sound, and touch to improve movement and thinking in Parkinson's disease
This study is testing a new method using light, sound, and touch to see if it can help people with mild Parkinson's disease move better and think more clearly.
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Gamma frequency stimulation for individuals with Down Syndrome
This study is testing if a new light and sound treatment can help improve thinking skills and slow down Alzheimer's risk in people with Down Syndrome.
NIH-funded research (newest 40 of 383)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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PhysioNet: A trusted, open data repository for clinical and physiological data
A publicly accessible platform provides curated clinical and physiological data and tools to help researchers develop and test AI models for better healthcare.
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Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate
Researchers will study how dormant cancer cells in liver and skin metastases of triple-negative breast cancer become quiescent or wake up, using organ-on-chip models and single-cell analysis to map chromatin states.
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Single-cell, label-free mapping of senescence in tissues with Raman imaging and spatial genomics
A project to map how senescent cells differ across tissues using a noninvasive Raman imaging method combined with spatial genomics.
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Structures and dynamics of virus ion channels
This project studies the tiny channels in certain influenza and coronavirus viruses to understand how they let ions pass through and contribute to disease.
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Prospect: Stem Cell Models for Early-Onset Colorectal Cancer Prevention
Researchers at MIT are using stem cell models to understand why colorectal cancer is rising in people under 50 and how to prevent it.
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MATCHMAKERS: AI tools to predict TCR binding and design
Researchers are building AI tools to predict how T cell receptors recognize tumor antigens, with aims to help improve targeted immunotherapies.
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Genetic tools to create better marmoset models of autism
This grant aims to develop and refine genome editing methods in marmosets to create better animal models of autism for understanding the condition.
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Visualizing how HIV-1 capsid moves through the cell’s doorway (nuclear pore)
Scientists are studying how the HIV-1 capsid travels through the cell’s nuclear pore to reach the nucleus, which could reveal new ways to block infection.
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How extra-chromosomal DNA (ecDNA) helps tumors grow and resist treatment
This project builds computer models and lab tools to track how ecDNA lets cancer cells change and survive, with the aim of helping people whose tumors are driven by ecDNA.
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Bioelectronics-powered meso-scale organ-on-a-chip to model neuromuscular disease
A new device will mimic how nerves and muscles work together, using soft electronics to stimulate and monitor multiple motor units to help understand and treat nerve injuries.
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Characterizing how excitatory brain connections form and change in living tissue
This grant studies how excitatory synapses in the brain are created or removed over time in living animals, focusing on how activity and specific molecules influence which connections are kept.
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Understanding what signals tell the liver to regrow after injury
This grant studies how the liver senses injury and triggers its own repair, aiming to improve recovery for people with acute liver failure.
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Cochlear implant strategies powered by machine learning
A machine-learning driven approach to improve how cochlear implants convert sound into electrical signals for people with severe hearing loss.
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Probing how endocannabinoids shape memory in the hippocampus using light-based brain sensing
A research team at MIT is studying how endocannabinoids influence memory by watching and controlling brain signals in behaving mice with advanced light-based tools.
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Changes in silent synapses and cognitive aging in humans and mice
A study aims to understand how changes in brain connections relate to aging and memory in adults and older adults, using humans and mice.
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Analytical Core for Deep Molecular Profiling of Brain Tumor Tissue
A central lab hub will perform advanced single-cell, bulk, and imaging analyses to map brain tumor cells and their surroundings from patient samples and model tissues.
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Biospecimens Core for glioblastoma research
A center-led program will provide high-quality human and animal tumor samples to advance glioblastoma research and translation.
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Education and Outreach Core for Glioblastoma research
A multi-institutional program to train people and share knowledge about glioblastoma using new data tools and collaborations.
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Understanding how tumors and the immune system interact in glioblastoma
A high-tech research project combines tumor and immune cell studies to find key pathways that drive glioblastoma progression and immune resistance, using patient-like models and advanced data analysis.
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Deciphering how glioblastoma interacts with brain cells to drive growth and resistance
A research team at MIT/DFCI is building a systems biology model of glioblastoma to map how tumor cells talk to brain cells and predict how the disease will progress and respond to therapy.
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Administrative Core supports glioblastoma research collaborations and data sharing
A core grant at MIT/DFCI helps scientists study how glioblastoma interacts with its surroundings by coordinating collaborations, managing data, and sharing biospecimens.
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Understanding glioblastoma and its communication with brain cells and the immune system
A large NIH grant aims to map how glioblastoma cancer cells talk to neurons and immune cells, with the goal of finding new ways to treat this aggressive brain tumor.
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Ultrafast eye imaging to detect and track diabetic retinopathy
A doctor-science team is developing ultra-fast eye scans to better see tiny blood vessels in people with diabetic retinopathy, helping catch changes early and guide treatment.
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PhysioNet: a widely accessible data repository for clinical and physiological data
A freely accessible, curated data repository and tools for managing and analyzing clinical and physiological data to support AI and ML in healthcare.
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Understanding how viral ion channels work to fight flu and COVID-19
Researchers study tiny protein channels in viruses like influenza and SARS-CoV-2 to learn how they operate, with hope of guiding new antiviral drugs.
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Endometrium model with tissue engineering and microfluidics
A study will create a 3D, lab-based model of the human endometrium to study how its cells interact and function during the crucial implantation phase.
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Targeting minimal residual disease in AML with smart imaging and AI
A patient-centered project to find better ways to treat residual leukemia cells after remission using advanced imaging and AI together with precise measurement tools.
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Chemical ways to block PAX3-FOXO1 in a dangerous childhood cancer
A study to find small molecules that can interfere with the cancer-driving PAX3-FOXO1 fusion protein in alveolar rhabdomyosarcoma, aiming to slow or stop tumor growth in affected children.
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Collagen Proteostasis: Keeping Collagen Healthy in the Body
A research project from MIT aims to understand how collagen is folded and quality-checked in healthy people and those with collagen-related diseases.
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A 3D, patient-tailored, soft implant toolkit to prevent stroke in AF patients
A new, minimally invasive approach aims to create a personalized, soft implant inside the heart to seal off a risky area and reduce stroke risk in people with atrial fibrillation.
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Revealing how membrane proteins change shape to send signals
This grant aims to understand how membrane proteins change shape to pass signals across cell membranes, which is important because many drugs target these proteins.
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Research Experience and Training Core for safer water and community health
A cancer-causing chemical project aims to train the next generation of biomedical and environmental scientists so they can study, monitor, and reduce harmful nitrosamines in communities.
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Community Engagement Core for Cancer and Environmental Health
A community-focused program at MIT works with local tribes and schools to teach biology and environmental health and reduce harmful N-nitrosamines in drinking water.
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Core Data Management and Analysis for N-nitrosamines and Cancer Risk
A data management and analysis core at MIT will organize and share information to help understand how N-nitrosamines may cause cancer and how to prevent exposure.
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Measuring and preventing N-nitrosamine exposure at home
A project at MIT aims to detect and reduce harmful N-nitrosamines in people’s homes by improving measurement methods and developing ways to destroy these chemicals before exposure.
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Methods for detecting and concentrating cancer-causing nitrosamines in water for easy at-home sensing
A project to develop inexpensive, user-friendly materials and sensors so people can detect harmful nitrosamines in drinking water without needing specialized labs.
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High-Resolution Mutation Maps and Multi-Omics to Understand Why Cancers Develop
A cancer-focused grant studies how environmental chemicals, especially at Superfund sites, may cause DNA changes and protein changes that could lead to cancer, using advanced sequencing and multi-omics in mice and human-derived samples.
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Health effects of N-nitrosamines and ways to reduce cancer risk
This grant explores how certain mutagenic chemicals called N-nitrosamines may cause cancer and develops tools to predict and reduce that risk.
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Protecting Health from Harmful N-nitrosamines in our communities
A project from MIT aims to understand and reduce the cancer risk from N-nitrosamines by developing quick smartphone sensors and animal models to study exposure and disease links.
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Comprehensive brain-mapping of the marmoset with cell type detail
A large NIH project will create a high-resolution map of how different brain regions connect in the common marmoset, using RNA barcodes to identify neuron types and a sequencing-based imaging method.
Quick answers
How many clinical trials run by Massachusetts Institute of Technology are recruiting right now?
9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.