Biospecimens Core for glioblastoma research
Official title: Core 1: Biospecimens Core
Funded at Massachusetts Institute of Technology · NIH-11420571 · Data updated 2026-11-12
A center-led program will provide high-quality human and animal tumor samples to advance glioblastoma research and translation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $329,154 |
| NIH project number | 5U54CA283114-04 |
| Project ID | NIH-11420571 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with glioblastoma who contribute tissue samples or participate in related biobanking activities, and individuals whose tissues may be used in correlative studies.
✕Less likely to help
Individuals not able to provide tissue or participate in associated biobanking activities may not directly benefit.
What this research studies
This grant supports a Biospecimens Core that coordinates access to patient-derived samples, animal models, and derived cultures (like organoids) to study glioblastoma. It integrates samples from neurosurgical patients and preclinical models (PDXs and GEMMs) to connect lab findings with real tumors. The core collaborates with top medical centers to ensure samples are well-characterized and suitable for translating discoveries into potential therapies. Researchers use these materials to map signaling pathways and test pharmacologic effects across both animal and human specimens, with reverse-translation opportunities to refine models.
Why it matters
Potential benefit: If successful, patients could benefit from accelerated discovery of effective glioblastoma treatments guided by well-matched human and animal samples.
How similar studies have gone: Prior work with matched human and animal samples has helped validate translational findings in glioblastoma, supporting this approach's potential.
Where this research is happening
-
Massachusetts Institute of Technology
Cambridge, United States Active
Researchers
- Principal investigator: Sarkaria, Jann N. — Massachusetts Institute of Technology
- Study coordinator: Sarkaria, Jann N.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.