Analytical Core for Deep Molecular Profiling of Brain Tumor Tissue
Official title: Core 2: Analytical Core
Funded at Massachusetts Institute of Technology · NIH-11420576 · Data updated 2026-11-12
A central lab hub will perform advanced single-cell, bulk, and imaging analyses to map brain tumor cells and their surroundings from patient samples and model tissues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $343,932 |
| NIH project number | 5U54CA283114-04 |
| Project ID | NIH-11420576 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with brain tumors (e.g., glioblastoma) whose tissue samples are used for multi-omics profiling.
✕Less likely to help
Patients whose samples are not used for research or whose condition is not part of the study scope may not directly benefit.
What this research studies
This grant funds a specialized core that links multiple molecular techniques—single-cell and bulk RNA/protein profiling, phosphoproteomics, immunopeptidomics, metabolomics, and mass spectrometry imaging—to create a high-resolution map of brain tumor biology and its microenvironment. It provides expert personnel, data management with FAIR principles, and access to multi-omics data from core biopsy samples to support projects studying brain tumors. The aim is to generate ultra-deep, spatially resolved molecular data that can guide future therapeutic strategies and biomarker discovery. Researchers and clinicians could use these resources to understand tumor biology and to plan targeted interventions based on molecular context.
Why it matters
Potential benefit: Patients with brain tumors could benefit from more precise molecular insights that inform targeted therapies and better biomarker discovery.
How similar studies have gone: This core builds on prior demonstrations of integrated multi-omics profiling in GBM and similar tumors, aligning with established multi-omics approaches.
Where this research is happening
-
Massachusetts Institute of Technology
Cambridge, United States Active
Researchers
- Principal investigator: Agar, Nathalie Yr — Massachusetts Institute of Technology
- Study coordinator: Agar, Nathalie Yr
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.