Neural-controlled powered knee and ankle for people with above-knee amputation.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-site interventional project will fit participants who have unilateral transfemoral amputation with an MIT Powered Leg that uses neural control and will have them perform a range of real-world mobility tasks. Investigators will compare walking symmetry, stability, and the user's sense of embodiment when using the powered prosthesis versus their prescribed prosthesis, collecting biomechanical and user-reported measures. Participants will be adults aged 18–70 with functional mobility at K3 level or above and an adequate socket to support the device. Results will inform future bionic prosthesis design and integration into daily life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or Female age 18-70.
* The patient must have a unilateral transfemoral amputation .
* The patient must have the ability to ambulate at variable cadence (an expected lower extremity prosthesis functional level of K3 or above).
* The patient must have adequate socket to support the device.

Exclusion Criteria:

* Women who are pregnant.
* Severe co morbidity, atypical skeletal anatomy, or poor general physical/mental health that, in the opinion of the Investigator, will not allow the subject to be a good study candidate (i.e. other disease processes, mental capacity, substance abuse, shortened life expectancy, vulnerable patient population, BMI \>40, etc.).

Where it's running

• MIT Media Lab
  Cambridge, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Hugh Herr — MIT Media Lab
• Study coordinator: John A McCullough, B.S. Mechanical Engineering
• Email: johnmccu@mit.edu
• Phone: 424-603-1074

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Personalizing powered knee prostheses using reinforcement learning

  This trial will test whether a computer system called RISE can help clinicians tune powered knee prostheses faster and make them work better for people with above-knee (transfemoral) amputations.

  Recruiting Phase 1 North Carolina State University · Raleigh, North Carolina · NCT07204925

• How residual limb length relates to strength, balance, and function after transfemoral amputation

  This study tests how the length of the missing lower leg segment affects strength, balance, and daily function in adults with a transfemoral amputation.

  Recruiting Hacettepe University · Ankara, Ankara · NCT07032233

• Evaluating the Ossur Power Knee for people with above-knee amputations

  This study is testing whether the Ossur Power Knee, a high-tech prosthetic knee that helps with movement, works better than a regular prosthetic knee for people with above-knee amputations.

  Recruiting VA Office of Research and Development · Chicago, Illinois · NCT06218238

• Improving prosthetic socket fit for veterans with lower limb amputations

  This study is testing whether an adjustable prosthetic socket can help veterans with lower limb amputations walk better and feel more comfortable compared to a regular socket.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT05989243

• Comparing walking with powered and passive prosthetic knees for amputees

  This study tests whether walking with a powered prosthetic knee is easier and more efficient for people with leg amputations compared to using a standard knee.

  Recruiting Loma Linda University · Loma Linda, California · NCT05831696

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.