Endometrium model with tissue engineering and microfluidics
Official title: Integrating tissue engineering and microfluidics to model the spatial niches of the human endometrium in vitro with guidance from in vivo multiomics data
Funded at Massachusetts Institute of Technology · NIH-11406082 · Data updated 2026-11-12
A study will create a 3D, lab-based model of the human endometrium to study how its cells interact and function during the crucial implantation phase.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 20, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $539,092 |
| NIH project number | 5R01HD114214-04 |
| Project ID | NIH-11406082 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with conditions affecting the endometrium or implantation who may participate through donated tissue samples or consenting to future related studies.
✕Less likely to help
People without endometrial concerns or those not contributing tissue samples may not directly benefit.
What this research studies
Researchers will combine tissue engineering and microfluidic techniques to build in vitro models that mimic the spatial organization of the endometrium. Using advanced single-cell and spatial data, they will design robust, scalable systems that reproduce the early-to-mid secretory phase of the lining. The goal is to provide a testable platform for understanding how cell communication and tissue structure influence implantation and related conditions. The work emphasizes reproducibility and accessibility for the broader research community, potentially informing treatments for infertility and endometrial disorders.
Why it matters
Potential benefit: If successful, patients could benefit from better insights into implantation-related infertility and new ways to study endometrial diseases.
How similar studies have gone: Preclinical models using tissue engineering and microfluidics have shown promise in recapitulating tissue-specific functions.
Where this research is happening
-
Massachusetts Institute of Technology
Cambridge, United States Active
Researchers
- Principal investigator: Griffith, Linda G — Massachusetts Institute of Technology
- Study coordinator: Griffith, Linda G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.