Sponsor or institution
Clinical trials and research at Durham VA Medical Center
As of November 12, 2026, Find a Trial lists 66 NIH-funded research projects at this institution. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 66NIH research projects
NIH-funded research (newest 40 of 66)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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PTSD, Faster Aging, and Veteran Health
A study to see whether PTSD makes aging happen faster in veterans and how this could affect their health and care.
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Adapting PTSD Treatments to Improve Keeping Veterans in Care
A study tests delivering PTSD therapies more frequently in a condensed schedule to help Veterans stay in treatment and finish proven therapies.
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Trauma-informed home-based exercise program for women veterans with sexual violence histories
A trauma-informed telehealth exercise program is being developed and tested to help women veterans who have experienced sexual violence feel better physically and mentally.
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Nutrition plan to help older adults with cancer recover after surgery
A multi-nutrient approach given around cancer surgery for older adults aims to preserve and restore physical function after treatment.
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Personalized Colorectal Cancer Prevention using Genetic Data to Guide Screening and Follow-Up
A VA-led project to tailor when and how often people get colon cancer screening based on their genetic and clinical risk.
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RBC SNO transport and endothelial sticking in sepsis
Researchers are studying how red blood cells and nitric oxide in sepsis patients might affect blood flow and why certain transfusion practices don’t always help.
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Outpatient palliative care for older veterans
This project compares different outpatient palliative care approaches to help older veterans with serious long-term illnesses feel better and get care that matches their goals.
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Remote supervised exercise to help Veterans with peripheral artery disease walk farther and feel better
A VA telehealth program offering supervised exercise to help Veterans with peripheral artery disease improve walking distance, quality of life, and heart health.
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Helping Veterans reduce their risk of heart disease with personalized statin therapy
This study is looking to help Veterans who are at high risk for heart problems by using genetic testing to find out how well statins will work for them, so they can feel more confident about taking their medication and lower their cholesterol safely.
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Hypertension care for Veterans with rheumatoid arthritis to prevent heart disease
A structured plan to improve blood pressure control in Veterans with rheumatoid arthritis to lower their risk of heart disease.
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Improving IPF care for Veterans with a new, practical care model
A project to help Veterans with idiopathic pulmonary fibrosis get timely, expert, and age-friendly care using a new care model.
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Adolescent and Young Adult Alcohol Exposure and Later Stress-Linked Anxiety
This project looks at how drinking during adolescence or young adulthood might increase the risk of anxiety and stress-related problems later, especially in military-connected individuals.
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Mobile tool to help reduce suicidal thoughts in Veterans
A small, patient-friendly phone app called MIST helps Veterans with suicidal thoughts by guiding them through quick, practical steps to change distressing beliefs.
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A new approach to help veterans with anxiety and depression feel better and function more normally
A new intervention using pregnenolone to help veterans with anxiety and depression reduce symptoms and improve daily function.
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Mobile Anger Reduction Tool for Veterans
A smartphone-based program to help Veterans with PTSD manage anger and reduce aggressive responses.
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How inflammatory signals make chronic kidney disease worse
Researchers are looking at whether proteins in kidney tubule cells help stop inflammation (TNF and IL-1β) from making chronic kidney disease worse, using animal models.
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Two neurosteroid medicines being tested for chronic low back pain in U.S. veterans
This project will compare two experimental neurosteroid medicines against a placebo to see if they safely ease chronic low back pain in U.S. military veterans.
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Investigating PTSD and its links to substance abuse and cardiovascular health
This study is looking at how PTSD affects veterans and their use of substances like smoking and alcohol, using different methods to find better ways to help those who are struggling.
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Improving care for Veterans with obesity and chronic conditions
This study is looking at how to improve health and care for Veterans who are dealing with obesity and other ongoing health issues, to find out which programs work best for them and create better care options.
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Short therapy to reduce self-injury and help Veterans function better
A nine-session, Veteran-adapted therapy uses real-time phone-based tracking to help people stop non-suicidal self-injury and improve daily functioning.
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Decision tool to help veterans with dementia and caregivers in the emergency room
Creates a short conversation aid to help veterans living with dementia, their caregivers, and ER clinicians decide whether to admit a patient or go home.
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How genes and life experiences affect suicide risk in Veterans
This project looks at how a Veteran's genes and life experiences combine to influence suicidal thoughts and behaviors.
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Genetic tools to predict who will get colorectal cancer and when
This project will build genetic-based tools to help predict which people are more likely to develop colorectal cancer and the likely timing so screening can be better personalized.
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Deciding whether to fill diabetes medicine through the VA or Medicare Part D
Researchers will create and try out a simple decision tool to help Veterans with adult-onset diabetes choose whether to fill their diabetes medicines through the VA or Medicare Part D.
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Improving access to care for Veterans
This study is all about making healthcare better for Veterans by finding ways to improve how quickly and easily they can get the care they need, so they can enjoy a healthier life.
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Virtual care tailored for women Veterans
This project aims to improve VA virtual health services so women Veterans can get more convenient, personalized care.
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Notched Noise Therapy for Tinnitus Relief
This project explores a special sound therapy called Notched Noise Therapy to help Veterans who experience ringing in their ears, also known as tinnitus.
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PTSD therapy combined with intensive smoking-cessation support for veterans who smoke
This project combines proven PTSD therapy with extra smoking-cessation counseling, nicotine support, and rewards-based coaching to help Veterans with PTSD quit cigarettes.
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Investigating a new treatment for chronic complex traumatic brain injury using a neurosteroid.
This study is testing a natural substance called Allopregnanolone to see if it can help veterans with chronic traumatic brain injury feel better by reducing symptoms like depression and pain.
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Using genetics to personalize statin treatment for Veterans
This project uses genetic test results to help Veterans at high risk for heart disease choose and stick with the right statin so they can lower their cholesterol and heart risk.
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Improving osteoporosis screening for older male veterans
This study is looking at new ways to help older male veterans find out if they have osteoporosis, so they can get the right care to prevent fractures, and it will compare two different methods to see which one works best.
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LGBTQ-affirming cognitive behavioral therapy for Veterans
This project will bring LGBTQ-affirming cognitive behavioral therapy to VA clinics to help LGBTQ+ Veterans get culturally safe mental health care.
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Home health aide and homemaker support to help Veterans stay at home
This project looks at how home health aides and homemaker services are used by Veterans with daily living difficulties and how those services relate to staying in the home versus moving to a nursing facility.
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A nurse-led program to help Veterans with HIV prevent heart disease.
This study is all about helping Veterans with HIV stay heart-healthy by teaching them about their risk for heart disease and making sure they get the right treatments for managing their blood pressure.
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Does PTSD speed up biological aging in Veterans
This project looks at whether Veterans with PTSD have signs of faster biological aging using blood-based markers so high-risk Veterans can be identified earlier.
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Using targeted brain stimulation to help Veterans with PTSD stop smoking
This project uses brain scans and targeted magnetic brain stimulation to help Veterans with PTSD quit smoking.
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Improving treatment for bleeding in the brain using Factor VIIa.
This study is looking at how to make a treatment called Factor VIIa work better for people with serious bleeding in the brain, like those with traumatic brain injuries, while also keeping them safe from side effects like inflammation and blood clots.
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Protecting kidney cells in diabetic kidney disease using signaling molecules
This study is looking at how certain natural substances can help protect kidney cells from damage caused by diabetes, with the hope of finding new treatments that could improve kidney health for people with diabetic kidney disease.
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Identifying molecular characteristics of Gulf War Veterans' illnesses
This study is looking at Gulf War Illness in Veterans to find specific markers in their blood that could help diagnose the condition and improve treatment options, using advanced technology to analyze samples from over 1,000 Veterans.
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Nutrition plan to protect strength and daily function in older adults with cancer around surgery
A multi-nutrient program given before and after cancer surgery to help older adults keep muscle, strength, and everyday abilities.
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