Improving treatment for bleeding in the brain using Factor VIIa.
Official title: Understanding and Enhancing the Therapeutic Efficacy of Factor VIIa for Emergency Hemostasis
Funded at Durham VA Medical Center · NIH-11109590 · Data updated 2026-11-12
This study is looking at how to make a treatment called Factor VIIa work better for people with serious bleeding in the brain, like those with traumatic brain injuries, while also keeping them safe from side effects like inflammation and blood clots.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Durham VA Medical Center NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5IK2BX005303-05 |
| Project ID | NIH-11109590 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have suffered from traumatic brain injuries or have experienced intracranial hemorrhages.
✕Less likely to help
Patients with conditions unrelated to bleeding disorders or those who do not have a history of traumatic brain injury may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of Factor VIIa, a treatment used to control bleeding in patients with intracranial hemorrhage (ICH) and traumatic brain injury (TBI). The study aims to understand how Factor VIIa can be used safely while minimizing the risk of complications such as inflammation and thrombosis. By investigating the dual role of this treatment in promoting hemostasis and reducing inflammation, the research seeks to improve patient outcomes for those suffering from severe bleeding in the brain.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients experiencing life-threatening brain bleeds.
How similar studies have gone: Previous research has shown promise in using Factor VIIa for managing hemorrhagic conditions, but this specific approach to enhance its efficacy while reducing complications is novel.
Where this research is happening
-
Durham VA Medical Center
Durham, United States Active
Researchers
- Principal investigator: Fager, Ammon M — Durham VA Medical Center
- Study coordinator: Fager, Ammon M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.