A new approach to help veterans with anxiety and depression feel better and function more normally

Who could benefit from this research

What this research studies

This grant focuses on a treatment that could help veterans who experience both anxiety and depression. It builds on prior work suggesting pregnenolone and related neurosteroids may ease worry, sadness, sleep problems, and pain. The study considers how restoring neurosteroid levels might translate into real-world improvements in daily activities, relationships, and quality of life. If successful, it could offer a new option that targets multiple symptoms at once. The research team at Durham VA Medical Center will pursue this approach with careful attention to safety and effectiveness in the veteran population.

Why it matters

Where this research is happening

• Durham VA Medical Center
  Durham, United States Active

Researchers

• Principal investigator: Naylor, Jennifer C — Durham VA Medical Center
• Study coordinator: Naylor, Jennifer C

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.