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Clinical trials and research at Children's National Research Institute

• 44Clinical trials
• 1New in 30 days
• 5Countries

Newest trials

All recruiting trials (44)

• Botox to improve scar after cleft lip repair

  This study tests whether a Botox injection given during cleft lip repair in infants can lead to better-looking scars in the first year after surgery.

  Recruiting Phase 2 Children's National Research Institute · Washington D.C., District of Columbia · NCT07880860

• Ultra-Rapid Drug Screening Guide for Relapsed Rare Brain Tumors

  This study tests a real-time, tissue-informed drug screening approach to guide personalized treatment for children and young adults with relapsed ultra-rare brain tumors.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07851636

• AI care summaries to help caregivers understand their child’s hospitalization

  This trial tests whether an AI-generated plain-language summary of inpatient notes helps caregivers of hospitalized children understand their child’s care better.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07831018

• Blood-brain barrier opening with focused ultrasound plus T-cell therapy for young DMG patients

  This phase 1 study tests whether opening the blood-brain barrier with focused ultrasound and microbubbles can be safely combined with infusion of tumor-targeted T cells in children and young adults with newly diagnosed diffuse midline glioma.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT07796061

• Pupillary Dilation Reflex in Healthy Adults

  A single-site, non-interventional study will see how healthy adults’ pupils dilate when exposed to different levels of neurostimulation using the AlgometRx device.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07746167

• Neuro-navigation-guided focused ultrasound with nivolumab for relapsed or progressive high-grade brain tumors in children

  This study tests whether using focused ultrasound to open the blood-brain barrier and give nivolumab is safe and feasible for kids with relapsed or progressive DMG/DIPG or other high-grade brain tumors.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT07664176

• Using pupillometry to measure acute pain in children and teens

  This project will test whether a non-invasive pupillometry device (AlgometRx Nociometer) can provide an objective measure of acute pain in children and adolescents ages 6 to 21 who are having elective surgery or undergoing bone marrow transplantation.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07336264

• Personalized B7-H3 CAR T cells combined with PRAME antigen-specific T cells for relapsed embryonal tumors

  This trial tests a combined personalized B7-H3 CAR T cell and PRAME-specific T cell infusion after lymphodepleting chemotherapy in children and young adults with relapsed or refractory embryonal tumors.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia and 1 other locations · NCT07172958

• Prototype anchor dressing for button gastrostomy tubes

  This study will test whether a new adhesive anchor dressing reduces accidental removal and clinic/ER visits for patients getting button gastrostomy tubes.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07115134

• TP53 gene therapy (SGT-53) with nivolumab and focused radiation for children with recurrent brain tumors

  This study tests a TP53 gene therapy called SGT-53 combined with the immune drug nivolumab and focused radiation in children whose brain tumors have come back, grown, or not responded to prior treatment.

  Recruiting Early Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT07017816

• Digital cognitive rehabilitation for youth with sickle cell disease

  This study is testing a digital program that helps kids and teens with sickle cell disease improve their thinking skills and memory while also providing social support.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06770010

• MeK and MDM2 inhibitors in NF1-related tumors

  This study tests a combination of selumetinib and APG-115 in adults and older teens with NF1 who have unresectable or metastatic MPNST or related conditions to see if the treatment is tolerable and helps slow or stop tumor growth.

  Recruiting at 2 sites Phase 1/2 Children's National Research Institute · Washington D.C., District of Columbia and 1 other locations · NCT06735820

• Using virtual reality to ease lumbar punctures in children with leukemia

  This study is testing whether using virtual reality can help kids with leukemia feel less pain and anxiety during lumbar punctures, so they might not need general anesthesia.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06722638

• Using intravenous L-citrulline to treat pain in sickle cell disease

  This study is testing if giving L-citrulline through an IV can help kids and young adults with sickle cell disease feel better faster during painful episodes.

  Recruiting Phase 2 Children's National Research Institute · Washington D.C., District of Columbia · NCT06635902

• Treating maternal depression in mothers of children with asthma

  This study is testing a new therapy for mothers with depression who have children with asthma to see if it helps improve their mental health and their child's asthma management.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06623981

• Virtual group mindfulness or diabetes education for teens with type 1 diabetes and mood symptoms

  This trial tests whether a virtual group mindfulness program or a virtual group diabetes-education program helps teens with type 1 diabetes who have symptoms of depression or anxiety.

  Recruiting Children's National Research Institute · Aurora, Colorado and 1 other locations · NCT06618027

• Adding dexamethasone to standard care for children and young adults with rhabdomyolysis

  This study will test whether giving dexamethasone alongside usual care helps children and young adults (6 months–25 years) with rhabdomyolysis have less pain, shorter hospital stays, and fewer kidney problems.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT06429982

• Exploring pregnancy and parenting experiences in individuals with Lyme disease

  This study looks at how having Lyme disease affects pregnancy and parenting experiences for those diagnosed with the condition.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06397794

• Transplant for Sickle Cell Disease Using a Nonmyeloablative Approach

  This study is testing a new way to help people with sickle cell disease who have certain antibodies receive a safer type of stem cell transplant from a sibling to see if it can improve their chances of recovery.

  Recruiting Phase 2 Children's National Research Institute · Washington D.C., District of Columbia · NCT06358638

• Personalized nutrition to support growth and brain development in preterm infants

  This study is testing whether a personalized nutrition plan for very preterm infants can help them grow better and develop their brains more effectively compared to standard milk fortification.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06266455

• Using augmented reality to assist MRI-guided needle procedures

  This study is testing a new augmented reality system to see if it can help doctors perform needle procedures more accurately and safely in young patients aged 3 to 21.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06224933

• Immunotherapy using personalized T cells for pediatric brain tumors

  This study is testing a new treatment using personalized immune cells to help young children with certain brain tumors that haven't completely gone away after standard treatment.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT06193759

• Evaluating inflammation in children with inflammatory bowel disease

  This study is testing a new device to see how it can help doctors understand inflammation in children with Crohn's disease and ulcerative colitis, so they can provide better treatment.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06065228

• Using focused ultrasound to treat dyskinetic cerebral palsy in young patients

  This study is testing a new ultrasound treatment to see if it can help young people with dyskinetic cerebral palsy who haven't found relief from other medications.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06036199

• Program to help children manage food allergies

  This study is testing a program to help early teens with food allergies and their caregivers learn how to manage allergies better and feel more confident.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06034678

• Assessing neurodevelopmental outcomes in infants exposed to Lyme disease during pregnancy

  This study is trying to see how being exposed to Lyme disease during pregnancy affects the brain development of babies from birth to 18 months.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06026969

• Optimizing transitions from hospital to home for children with asthma

  This study is testing if extra support from an asthma navigator can help children with asthma and their caregivers manage their condition better after leaving the hospital.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT05991115

• Registry for rare brain tumors in children and young adults

  This study is collecting samples and health information from children and young adults with rare brain tumors to learn more about these conditions and improve treatment over the next 10 years.

  Recruiting at 13 sites Children's National Research Institute · Los Angeles, California and 12 other locations · NCT05697874

• Training program to improve attention in childhood cancer survivors

  This study is testing if a special video game can help improve attention and thinking skills in kids aged 8-16 who have survived leukemia or brain tumors.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT05528939

• Using omalizumab to prevent asthma exacerbations in children

  This study is testing if a single dose of omalizumab can help children aged 6-17 with asthma avoid worsening symptoms during colds and infections.

  Recruiting Phase 2 Children's National Research Institute · Washington D.C., District of Columbia · NCT05332067

• Using T cells to treat high-risk solid tumors

  This study is testing a new type of immune therapy using T cells to see if it can help people with high-risk solid tumors that haven't improved with standard treatments.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT05238792

• T cell therapy to prevent COVID-19 in immunocompromised patients

  This study is testing if a new T cell therapy can help prevent COVID-19 in immunocompromised patients who have had a stem cell transplant.

  Recruiting at 2 sites Phase 1 Children's National Research Institute · Washington D.C., District of Columbia and 1 other locations · NCT05141058

• Training program to improve attention in children with sickle cell disease

  This study is testing a fun, game-like training program to see if it can help children with sickle cell disease improve their attention and thinking skills.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT05099874

• Developing a way to measure treatment effects in children with rheumatologic conditions

  This study is trying to find a better way to measure how well treatments work for kids with certain rheumatologic conditions like Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus, and Fibromyalgia.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT04833465

• Measuring nerve damage in children receiving chemotherapy

  This study is testing a new way to measure nerve damage in children and teens with leukemia who are getting a chemotherapy drug called vincristine, to see if it helps catch problems earlier.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT04786977

• T-cell therapy for chronic norovirus in immunocompromised patients

  This study is testing a new T-cell therapy for people with chronic norovirus infections who have weakened immune systems to see if it's safe for them.

  Recruiting at 3 sites Phase 1 Children's National Research Institute · Washington D.C., District of Columbia and 2 other locations · NCT04691622

• Identifying brain injury biomarkers in patients with high ammonia levels

  This study is testing if certain brain injury markers in patients with high ammonia levels can help us understand how ammonia affects the brain and improve care for those with related metabolic disorders.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT04602325

• Using health technology to improve STI detection in adolescents

  This study tests if using a special electronic tool in emergency rooms can help doctors find more sexually transmitted infections in teens and young adults aged 15-21 compared to regular care.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT04372875

• Improving STI treatment adherence in adolescents using mobile health

  This study is testing if sending text message reminders can help teenagers stick to their treatment for sexually transmitted infections better than usual care.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT04372485

• Measuring pain management in children and adolescents

  This study is testing new ways to measure and manage pain in children and teens aged 7 to 21 who are getting pain relief treatments at a hospital.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT03794362

• Reducing toxicity in sibling donor transplants for children with sickle cell disease

  This study is testing a gentler transplant method for children with sickle cell disease using cells from their siblings to see if it reduces side effects while still helping them stay healthy.

  Recruiting at 7 sites Phase 2 Children's National Research Institute · Washington D.C., District of Columbia and 6 other locations · NCT03587272

• Surveillance of Carbaglu for NAGS deficiency

  This study is tracking the long-term safety of Carbaglu for people with NAGS deficiency to see how well it works and if there are any side effects.

  Recruiting at 3 sites Children's National Research Institute · Washington D.C., District of Columbia and 2 other locations · NCT03409003

• Treatment of high-risk hematopoietic malignancies using specialized immune cells

  This study is testing if special immune cells can help improve outcomes for patients with high-risk blood cancers, including those who have had or will have a stem cell transplant.

  Recruiting at 2 sites Phase 1 Children's National Research Institute · Washington D.C., District of Columbia and 1 other locations · NCT02203903

• Collecting samples from children with brainstem tumors

  This study is trying to collect samples from children with brainstem tumors to see if they can find genetic clues that might help create better treatments for these tough cancers.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT01106794

Quick answers

How many clinical trials run by Children's National Research Institute are recruiting right now?

44, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (44 trials), Brazil (1 trial), Colombia (1 trial), Israel (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 9, Phase 2: 5, Early Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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