Pupillary Dilation Reflex in Healthy Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll healthy adults aged 18 to 60 to measure pupillary dilation reflex (PRD) in response to increasing neurostimulation intensities. No therapeutic intervention will be given. Data will be collected at a single site to characterize PRD under varying stimulation levels and document responses with pupillometry. The study aims to establish how PRD correlates with stimulation intensity in a healthy population. Participation requires informed consent and compliance with study procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-60 years.
* In good general health (self-reported).
* Able and willing to provide written informed consent.

Exclusion Criteria:

* Eye pathology that prevents accurate pupillometry.
* Pregnancy (Self-Report)
* Diagnosis of autoimmune disorders.
* Diagnosis of any neuropathic disorder
* Inability to complete questionnaires.

Where it's running

• Children's National Hospital
  Washington D.C., District of Columbia, United States Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Botox to improve scar after cleft lip repair

  This study tests whether a Botox injection given during cleft lip repair in infants can lead to better-looking scars in the first year after surgery.

  Recruiting Phase 2 Children's National Research Institute · Washington D.C., District of Columbia · NCT07880860

• Ultra-Rapid Drug Screening Guide for Relapsed Rare Brain Tumors

  This study tests a real-time, tissue-informed drug screening approach to guide personalized treatment for children and young adults with relapsed ultra-rare brain tumors.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07851636

• AI care summaries to help caregivers understand their child’s hospitalization

  This trial tests whether an AI-generated plain-language summary of inpatient notes helps caregivers of hospitalized children understand their child’s care better.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07831018

• Blood-brain barrier opening with focused ultrasound plus T-cell therapy for young DMG patients

  This phase 1 study tests whether opening the blood-brain barrier with focused ultrasound and microbubbles can be safely combined with infusion of tumor-targeted T cells in children and young adults with newly diagnosed diffuse midline glioma.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT07796061

• Neuro-navigation-guided focused ultrasound with nivolumab for relapsed or progressive high-grade brain tumors in children

  This study tests whether using focused ultrasound to open the blood-brain barrier and give nivolumab is safe and feasible for kids with relapsed or progressive DMG/DIPG or other high-grade brain tumors.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia · NCT07664176

• Using pupillometry to measure acute pain in children and teens

  This project will test whether a non-invasive pupillometry device (AlgometRx Nociometer) can provide an objective measure of acute pain in children and adolescents ages 6 to 21 who are having elective surgery or undergoing bone marrow transplantation.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07336264

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.