Type 1 Diabetes TrialNet Clinical Network Hub
Funded at Benaroya Research Inst at Virginia Mason · NIH-11411486 · Data updated 2026-11-12
A national network hub is funded to speed up screening, recruitment, and sharing results for trials aimed at preserving beta cell function in people with type 1 diabetes or at risk for it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 9, 2014 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,000,000 |
| NIH project number | 5U01DK103282-12 |
| Project ID | NIH-11411486 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with type 1 diabetes or those at risk who may participate in screening and prevention trials coordinated by TrialNet.
✕Less likely to help
People not eligible for TrialNet screening or trials may not directly benefit.
What this research studies
If you or your child have type 1 diabetes or are at risk, this program helps coordinate trials and share information so new treatments can be tried faster. It focuses on keeping beta cells alive, not just managing insulin, by connecting sites, participants, and researchers. The work involves coordinating screening, enrollment, trial implementation, and dissemination of findings through a centralized hub in Seattle. This is a long-term effort designed to streamline research activities across TrialNet to benefit patients with or at risk for T1D.
Why it matters
Potential benefit: If successful, it could accelerate access to therapies that preserve beta cell function and improve long-term outcomes for people with T1D or those at risk.
How similar studies have gone: TrialNet has previously contributed to understanding disease progression and testing therapies; this hub aims to enhance those efforts.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Greenbaum, Carla J — Benaroya Research Inst at Virginia Mason
- Study coordinator: Greenbaum, Carla J
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.