Immune tolerance research network for safer transplant and autoimmune therapies
Official title: Immune Tolerance Network
Funded at Benaroya Research Inst at Virginia Mason · NIH-11609233 · Data updated 2026-11-12
A national effort tests new treatments that make the immune system tolerate transplanted organs and fight autoimmune and allergic diseases more safely.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | February 1, 2014 |
| Project end | January 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,822,074 |
| NIH project number | 3UM1AI109565-13S4 |
| Project ID | NIH-11609233 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with autoimmune or allergic conditions or those awaiting organ transplantation who are eligible for tolerance-related therapies.
✕Less likely to help
Patients not eligible for tolerance therapies or without conditions covered by this program may not benefit.
What this research studies
This initiative runs high-quality clinical trials of promising tolerance therapies and pairs them with advanced immunology lab work to understand how patients respond. It covers multiple diseases related to immune reactions, aiming to speed the development of safer, more effective options. Researchers collaborate across many sites to adapt strategies quickly as new data emerge, with a focus on real-world patient impact.
Why it matters
Potential benefit: If successful, this effort could lead to safer organ transplants and better treatments for autoimmune and allergic diseases.
How similar studies have gone: Previous tolerance-focused trials have shown proof-of-concept, but large-scale, cross-disease validation remains ongoing.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Buckner, Jane Hoyt — Benaroya Research Inst at Virginia Mason
- Study coordinator: Buckner, Jane Hoyt
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.