Vascular Triggers of Anesthesia-Related Low Blood Pressure in the Old and Very Young
Official title: Vascular Determinants of Anesthesia-Induced Hypotension at the Extremes of Age
Funded at Johns Hopkins University · NIH-11360616 · Data updated 2026-11-12
This NIH grant explores why people at the youngest and oldest ages are more likely to have dangerously low blood pressure during general anesthesia and how to prevent it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $409,375 |
| NIH project number | 5R35GM151175-05 |
| Project ID | NIH-11360616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older, neonates and infants, and elderly patients undergoing surgery who are at risk for intraoperative hypotension.
✕Less likely to help
Patients without extremes of age or those not undergoing surgery may not directly benefit from this research.
What this research studies
The project looks at how blood vessels behave differently in neonates, infants, and older adults when they are under anesthesia. It combines lab studies and animal or cellular models with real-world data to uncover why hypotension happens at the extremes of age. The goal is to identify vascular factors that contribute to inadequate organ blood flow during surgery and to inform safer anesthesia practices for these patients.
Why it matters
Potential benefit: If successful, the findings could lead to targeted strategies to keep blood pressure stable during anesthesia for young and elderly patients, reducing complications.
How similar studies have gone: Previous research has linked intraoperative hypotension to worse outcomes, and this project builds on that by focusing on vascular factors at age extremes.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Whitaker, Emmett E — Johns Hopkins University
- Study coordinator: Whitaker, Emmett E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.