NIH-funded research R01 grant

A device to help manage low blood pressure when standing in older adults

Official title: Automated Abdominal Binder for Orthostatic Hypotension

Funded at Vanderbilt University Medical Center · NIH-10753526 · Data updated 2026-11-12

This study is testing a special belt that helps older adults with neurogenic orthostatic hypotension, a condition that makes them feel dizzy or faint when they stand up, by giving gentle support to improve their blood flow and keep their blood pressure steady.

More Hypotension research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionVanderbilt University Medical Center
NIH-funded
Lab location1 site (Nashville, United States)
Project startJanuary 1, 2020
Project endDecember 31, 2025
Funding year2024
Award (this year)$518,259
NIH project number5R01HL144568-05
Project IDNIH-10753526 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are older adults diagnosed with neurogenic orthostatic hypotension who experience significant blood pressure drops upon standing.

Less likely to help

Patients who do not have neurogenic orthostatic hypotension or those with other unrelated medical conditions may not benefit from this research.

What this research studies

This research focuses on developing an automated abdominal binder designed to assist elderly patients suffering from neurogenic orthostatic hypotension (nOH), a condition that causes significant drops in blood pressure when standing. The device uses an accelerometer to detect when a patient is upright and applies controlled compression to improve blood flow and stabilize blood pressure. Unlike traditional drug therapies, this device aims to address the underlying causes of nOH without causing adverse effects when the patient is seated or lying down. Preliminary results indicate that the binder can enhance blood pressure and tolerance to standing in affected patients.

Why it matters

Potential benefit: If successful, this research could significantly improve the quality of life for elderly patients by reducing the risk of falls and enhancing their ability to stand safely.

How similar studies have gone: Other research has shown promising results with similar mechanical approaches to managing blood pressure in patients with orthostatic hypotension, indicating potential for success in this novel device.

Where this research is happening

  • Vanderbilt University Medical Center
    Nashville, United States
    Active

Researchers

  • Principal investigator: Okamoto, Luis Enrique — Vanderbilt University Medical Center
  • Study coordinator: Okamoto, Luis Enrique

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.