A device to help manage low blood pressure when standing in older adults
Official title: Automated Abdominal Binder for Orthostatic Hypotension
Funded at Vanderbilt University Medical Center · NIH-10753526 · Data updated 2026-11-12
This study is testing a special belt that helps older adults with neurogenic orthostatic hypotension, a condition that makes them feel dizzy or faint when they stand up, by giving gentle support to improve their blood flow and keep their blood pressure steady.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | January 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $518,259 |
| NIH project number | 5R01HL144568-05 |
| Project ID | NIH-10753526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with neurogenic orthostatic hypotension who experience significant blood pressure drops upon standing.
✕Less likely to help
Patients who do not have neurogenic orthostatic hypotension or those with other unrelated medical conditions may not benefit from this research.
What this research studies
This research focuses on developing an automated abdominal binder designed to assist elderly patients suffering from neurogenic orthostatic hypotension (nOH), a condition that causes significant drops in blood pressure when standing. The device uses an accelerometer to detect when a patient is upright and applies controlled compression to improve blood flow and stabilize blood pressure. Unlike traditional drug therapies, this device aims to address the underlying causes of nOH without causing adverse effects when the patient is seated or lying down. Preliminary results indicate that the binder can enhance blood pressure and tolerance to standing in affected patients.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for elderly patients by reducing the risk of falls and enhancing their ability to stand safely.
How similar studies have gone: Other research has shown promising results with similar mechanical approaches to managing blood pressure in patients with orthostatic hypotension, indicating potential for success in this novel device.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Okamoto, Luis Enrique — Vanderbilt University Medical Center
- Study coordinator: Okamoto, Luis Enrique
Related research
Other NIH-funded projects on the same topics.
-
Nighttime CPAP to lower high blood pressure when lying down and reduce daytime dizziness
This work uses nighttime CPAP for people with neurogenic orthostatic hypotension and supine hypertension to lower blood pressure while lying down and help reduce nighttime urination and daytime lightheadedness.
-
Using positive airway pressure to manage blood pressure issues in older adults
This study is looking at how using a CPAP machine, which helps with breathing during sleep, might lower high blood pressure that some older adults experience when lying down, and it hopes to make them feel better when they stand up during the day.
-
Vascular Triggers of Anesthesia-Related Low Blood Pressure in the Old and Very Young
This NIH grant explores why people at the youngest and oldest ages are more likely to have dangerously low blood pressure during general anesthesia and how to prevent it.
-
Understanding Blood Pressure Drops During Anesthesia in Very Young and Older Patients
This work explores why very young children and older adults often experience low blood pressure during surgery and how their blood vessels play a role.
-
How blood vessel properties affect anesthesia-related low blood pressure in very young and older patients
This study is looking into why babies and older adults often have low blood pressure when they are put under anesthesia, so we can find better ways to keep them safe during surgery.
-
Wearable device to monitor blood pressure after surgery
This study is testing a comfortable wearable device that keeps an eye on your blood pressure after surgery, helping to quickly alert caregivers if it drops too low, so you can stay safe and recover better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.