Understanding lung problems after TB in teens
Official title: Mechanisms Leading to Tuberculosis-Related Respiratory Sequelae in Adolescents
Funded at Rhode Island Hospital · NIH-11394315 · Data updated 2026-11-12
This project looks at why some teenagers who were treated for TB still have breathing problems and how to prevent or treat this later.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | August 16, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $287,219 |
| NIH project number | 5P20GM156688-02 |
| Project ID | NIH-11394315 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adolescents and young adults who have completed TB treatment and may have or be at risk for PTLD.
✕Less likely to help
Teens or adults without history of TB or PTLD are unlikely to benefit.
What this research studies
The grant focuses on adolescents who had TB and now experience post- TB lung disease. Researchers will study how lung growth during adolescence may influence the risk and severity of long-term breathing problems. The work aims to identify mechanisms and risk factors so clinicians can recognize and address PTLD early. By studies in a real patient population, the project seeks to lay groundwork for better prevention and treatment options for teen TB survivors.
Why it matters
Potential benefit: If successful, this work could lead to earlier diagnosis and tailored therapies to protect or restore lung function in adolescents after TB.
How similar studies have gone: Preliminary data in adolescent TB survivors suggest a substantial PTLD burden, but detailed mechanisms are not yet clear.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Chiang, Silvia Shinpei — Rhode Island Hospital
- Study coordinator: Chiang, Silvia Shinpei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.