Understanding how the optic nerve head changes in glaucoma.
Biomechanics of the Human Optic Nerve Head for Glaucoma Biomarkers.
This study is looking at how changes in eye pressure affect the optic nerve in people with glaucoma, aiming to find signs that could help predict nerve damage, so if you have open-angle glaucoma, your participation could help improve understanding and treatment of the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10856149 on NIH RePORTER |
What this research studies
This research investigates the biomechanics of the optic nerve head in patients with glaucoma, a leading cause of blindness. By using advanced imaging techniques, researchers will analyze how changes in intraocular pressure affect the optic nerve head's structure and function. The study aims to identify specific biomechanical markers that could predict the risk of axon injury in individuals with open-angle glaucoma. Patients will undergo imaging before and after changes in eye pressure to gather critical data on these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary open-angle glaucoma at various stages of the disease.
Not a fit: Patients with other types of glaucoma or those without any form of glaucoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and preventing vision loss in glaucoma patients.
How similar studies have performed: Previous research has shown promise in using biomechanical assessments to understand glaucoma, but this specific approach is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Nguyen, Thao D — Johns Hopkins University
- Study coordinator: Nguyen, Thao D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.