Understanding how temperature affects seizures in children
Official title: A developmental mechanism of temperature-sensitive seizures towards therapeutic manipulation
Funded at Children's Hosp of Philadelphia · NIH-11071569 · Data updated 2026-11-12
This study is looking into how fever can cause seizures in young kids, especially those between 6 months and 5 years old, to help find new ways to prevent these seizures and lower the chances of future epilepsy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $596,146 |
| NIH project number | 1R01NS137604-01A1 |
| Project ID | NIH-11071569 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0 to 5 years who experience febrile seizures.
✕Less likely to help
Patients who do not experience febrile seizures or are older than 5 years may not benefit from this research.
What this research studies
This research investigates the mechanisms behind febrile seizures, which are common in young children, particularly between 6 months and 5 years of age. The study aims to uncover how temperature changes can lead to these seizures by examining the behavior of specific brain cells during critical developmental periods. By using advanced techniques, researchers will explore the relationship between temperature and the generation of electrical signals in the brain that can trigger seizures. The ultimate goal is to develop new strategies to prevent these seizures and reduce the risk of future epilepsy in affected children.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent febrile seizures and reduce the risk of developing epilepsy in children.
How similar studies have gone: Previous research has shown promise in understanding seizure mechanisms, but this specific approach to temperature sensitivity in febrile seizures is relatively novel.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Goldberg, Ethan M — Children's Hosp of Philadelphia
- Study coordinator: Goldberg, Ethan M
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Disentangling How Inhibitory Brain Cells Shape Seizures in People
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.