Understanding how sleep apnea may raise Alzheimer’s risk in older Black adults

Who could benefit from this research

What this research studies

The study uses a disparities framework to explore how sleep apnea affects Alzheimer’s-related brain changes in Black older adults. It will compare how OSA influences brain pathology and inflammation, and whether cognitive decline links to these factors. The team will also examine how education, income, and neighborhood factors may explain differences in outcomes between Black and White participants. By identifying potential mechanisms like sleep patterns and inflammation, the research aims to guide more personalized care in this population.

Why it matters

Where this research is happening

• New York University School of Medicine
  New York, United States Active

Researchers

• Principal investigator: Bubu, Omonigho a Michael — New York University School of Medicine
• Study coordinator: Bubu, Omonigho a Michael

Related research

Other NIH-funded projects on the same topics.

• Investigating the link between obstructive sleep apnea and Alzheimer's disease risk in older Black individuals

  This study is looking at how sleep apnea might increase the risk of Alzheimer's disease in older Black adults, focusing on how sleep patterns and inflammation play a role, with the goal of finding better ways to support those at risk.

  NIH research New York University School of Medicine · New York, United States · NIH-11076339

• Investigating the link between obstructive sleep apnea and Alzheimer's disease

  This study is looking at how sleep apnea might be linked to Alzheimer's disease in older adults, and it aims to find out if oxygen therapy can help improve thinking skills for those affected.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10861744

• Sleep Apnea, Memory, and Alzheimer's Disease in World Trade Center Responders

  This project looks at how sleep apnea might be connected to memory changes and early signs of Alzheimer's disease in people who responded to the World Trade Center events.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11070195

• Investigating how sleep apnea affects cognition and Alzheimer's disease in World Trade Center responders

  This study is looking at how sleep apnea might affect thinking and memory in people who were exposed to World Trade Center dust, to see if improving sleep could help lower the risk of developing Alzheimer's disease.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10842220

• Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model

  Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.

  NIH research Nathan S. Kline Institute for Psych Res · Orangeburg, United States · NIH-11627965

• Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients

  A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11627145

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.