Investigating the link between obstructive sleep apnea and Alzheimer's disease

Who could benefit from this research

What this research studies

This research explores how obstructive sleep apnea (OSA), a condition that disrupts breathing during sleep, may contribute to the development of Alzheimer's disease, particularly in older adults. The study aims to understand the mechanisms behind this connection, including the roles of oxidative stress and the accumulation of amyloid and tau proteins in the brain. By using innovative, minimally invasive methods, researchers will assess the pathophysiology of OSA and its impact on cognitive functions. The project will also evaluate the effectiveness of oxygen therapy in OSA patients who are at risk for Alzheimer's, with the goal of improving cognitive outcomes.

Why it matters

Where this research is happening

• University of California, San Diego
  La Jolla, United States Active

Researchers

• Principal investigator: Malhotra, Atul — University of California, San Diego
• Study coordinator: Malhotra, Atul

Related research

Other NIH-funded projects on the same topics.

• Understanding how sleep apnea may raise Alzheimer’s risk in older Black adults

  This project looks at why sleep apnea might help explain why older Black people have a higher risk of Alzheimer’s disease.

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• Investigating the link between obstructive sleep apnea and Alzheimer's disease risk in older Black individuals

  This study is looking at how sleep apnea might increase the risk of Alzheimer's disease in older Black adults, focusing on how sleep patterns and inflammation play a role, with the goal of finding better ways to support those at risk.

  NIH research New York University School of Medicine · New York, United States · NIH-11076339

• Sleep Apnea, Memory, and Alzheimer's Disease in World Trade Center Responders

  This project looks at how sleep apnea might be connected to memory changes and early signs of Alzheimer's disease in people who responded to the World Trade Center events.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11070195

• Investigating how sleep apnea affects cognition and Alzheimer's disease in World Trade Center responders

  This study is looking at how sleep apnea might affect thinking and memory in people who were exposed to World Trade Center dust, to see if improving sleep could help lower the risk of developing Alzheimer's disease.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10842220

• Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model

  Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.

  NIH research Nathan S. Kline Institute for Psych Res · Orangeburg, United States · NIH-11627965

• Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients

  A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11627145

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.