Investigating how sleep apnea affects cognition and Alzheimer's disease in World Trade Center responders
Role of Sleep Apnea in Cognition and Alzheimer's Disease Biomarkers in WTC Responders
This study is looking at how sleep apnea might affect thinking and memory in people who were exposed to World Trade Center dust, to see if improving sleep could help lower the risk of developing Alzheimer's disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10842220 on NIH RePORTER |
What this research studies
This research explores the connection between sleep apnea and cognitive decline in individuals exposed to World Trade Center dust. It focuses on how disturbances in sleep may contribute to the development of Alzheimer's disease by examining biomarkers like amyloid beta and tau. The study aims to determine if sleep apnea is a modifiable risk factor for Alzheimer's and if sleep disturbances can serve as early indicators of the disease. Participants will undergo assessments to evaluate their sleep patterns and cognitive function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are World Trade Center responders who are experiencing sleep apnea and may be at risk for cognitive decline.
Not a fit: Patients who do not have sleep apnea or are not World Trade Center responders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive decline in individuals with sleep apnea, potentially delaying or preventing the onset of Alzheimer's disease.
How similar studies have performed: Previous research has indicated a link between sleep disturbances and cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Ayappa, Indu a — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ayappa, Indu a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.