Which patients' cirrhosis is likely to get worse and whether statins help
Evaluating risk factors for cirrhosis progression and response to statin therapy among a cohort of patients with cirrhosis
This work looks at whether statin medicines help people with compensated cirrhosis and which health factors make cirrhosis get worse.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11168816 on NIH RePORTER |
What this research studies
From a patient's perspective, this project follows people with compensated cirrhosis from different causes (alcohol-related liver disease, NASH, prior viral hepatitis, and HIV co-infection) to track who progresses to decompensation. Researchers will collect clinical data, labs, medication use, and outcomes over time and compare people who take statins with those who do not. The study aims to identify risk factors that predict faster decline and to determine the safety and potential protective effect of statins in a U.S. cohort. Participation will likely involve clinic visits and review of medical records.
Who could benefit from this research
Good fit: Adults with compensated cirrhosis of varied causes (including alcohol-related disease, NASH, or HIV co-infection) who are not yet decompensated and can attend clinic follow-up.
Not a fit: People with decompensated cirrhosis, active severe liver failure, children, or those with medical contraindications to statins are unlikely to benefit from this effort.
Why it matters
Potential benefit: If successful, this work could show that statins safely slow cirrhosis progression and reduce the risk of serious liver complications.
How similar studies have performed: Prior observational and retrospective studies suggest statins may lower complications of cirrhosis, but prospective or randomized evidence in compensated cirrhosis remains limited.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Goldberg, David Seth — University of Miami School of Medicine
- Study coordinator: Goldberg, David Seth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.