Understanding how persistent viruses affect sepsis in children
Official title: Modulation of Pediatric Sepsis by Virus Persistence
Funded at University of Michigan at Ann Arbor · NIH-11128024 · Data updated 2026-11-12
This study is looking at how ongoing viral infections might affect children with sepsis, a serious illness, to find new ways to understand their condition and improve treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | May 12, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $721,728 |
| NIH project number | 1R01AI184463-01A1 |
| Project ID | NIH-11128024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients aged 0-11 years who are diagnosed with sepsis.
✕Less likely to help
Patients who do not have sepsis or are older than 11 years may not benefit from this research.
What this research studies
This research investigates the role of persistent viral infections in children suffering from sepsis, a severe condition that can lead to multi-organ dysfunction. The team aims to identify novel biomarkers that can help classify different sepsis phenotypes and predict how patients will respond to immunomodulatory therapies. By studying common DNA viruses and their impact on inflammation and clinical outcomes, the research seeks to improve treatment strategies for pediatric patients with sepsis. The approach includes analyzing laboratory evidence of viral persistence and its effects on immune responses.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies for children with sepsis, improving their chances of recovery and reducing complications.
How similar studies have gone: Previous research has shown promising results in understanding the impact of viral infections on sepsis outcomes, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Weinberg, Jason Brice — University of Michigan at Ann Arbor
- Study coordinator: Weinberg, Jason Brice
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.