Understanding how genetic differences affect tuberculosis infection outcomes
Official title: Linking Mycobacterium Tuberculosis infection outcomes with transcriptional networks in genetically diverse mouse macrophages
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11165433 · Data updated 2026-11-12
This study is looking at how our genes might affect how we respond to tuberculosis, using mice to see why some people get really sick while others don’t show any symptoms, with the hope of finding better treatments that fit each person's genetic makeup.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $34,566 |
| NIH project number | 1F31AI191705-01 |
| Project ID | NIH-11165433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of tuberculosis infection, particularly those who have experienced varying disease outcomes.
✕Less likely to help
Patients who have never been infected with tuberculosis or those with non-genetic related conditions may not benefit from this research.
What this research studies
This research investigates how genetic variations influence the outcomes of tuberculosis (TB) infections by examining macrophages, which are key immune cells. Using genetically diverse mouse models, the study aims to link specific genetic variants to different responses to Mycobacterium Tuberculosis. By analyzing transcriptional networks in these cells, researchers hope to uncover why some individuals experience severe disease while others remain asymptomatic. The findings could lead to improved treatment strategies tailored to genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for tuberculosis based on individual genetic makeup.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on infectious diseases, suggesting that this approach could yield valuable insights into tuberculosis.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Fujimori, Gavin — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Fujimori, Gavin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.