Understanding how genes and environment affect glaucoma risk
Official title: PAGE-G: Precision Approach combining Genes and Environment in Glaucoma
Funded at University of California, San Diego · NIH-10797646 · Data updated 2026-11-12
This study is looking at how our genes and environment can affect the chances of getting glaucoma, a condition that can cause blindness, and it aims to help identify people at higher risk so they can get better early care, especially in different communities.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $316,000 |
| NIH project number | 1R03EY035824-01 |
| Project ID | NIH-10797646 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of glaucoma or those from diverse ethnic backgrounds who may be at higher risk.
✕Less likely to help
Patients with no family history of glaucoma or those who do not belong to high-risk populations may not benefit from this research.
What this research studies
This research investigates the genetic and environmental factors that contribute to the risk of developing glaucoma, a leading cause of blindness. By utilizing data from the All of Us Research Program, the study aims to create more accurate polygenic risk scores (PRS) that can identify individuals at high risk for glaucoma, particularly in diverse populations. The approach includes analyzing whole genome sequencing data and developing models that consider both genetic variants and their regulatory activities. This could lead to better early detection and treatment strategies for glaucoma.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and personalized treatment options for individuals at risk of glaucoma.
How similar studies have gone: Previous research has shown promise in using polygenic risk scores for other conditions, suggesting potential success for this innovative approach in glaucoma.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Baxter, Sally Liu — University of California, San Diego
- Study coordinator: Baxter, Sally Liu
Related research
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Using AI on eye scans and genes to predict glaucoma risk
This project uses artificial intelligence on eye scans, vision tests, and genetic information to find people most likely to develop or have worsening glaucoma.
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A new, easy-to-use AI screening approach will be tested in federally funded health centers to help identify people at risk for glaucoma, especially in communities with higher risk.
-
Understanding how glaucoma genes control eye cell function
A long-term research project will study how genetic factors affect eye cells in adults with glaucoma to uncover new ideas for protecting vision.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.