Understanding how COVID-19 affects tuberculosis infections
Official title: Tuberculosis Immunopathogenesis During Superinfection with SARS-CoV2
Funded at University of Wisconsin-Madison · NIH-11079637 · Data updated 2026-11-12
This study looks at how getting COVID-19 affects people who already have tuberculosis, aiming to understand how the two infections interact and what that means for treatment, so we can better help those dealing with both illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | May 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $749,747 |
| NIH project number | 5R01AI173411-03 |
| Project ID | NIH-11079637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are co-infected with Mycobacterium tuberculosis and SARS-CoV-2.
✕Less likely to help
Patients who are not infected with either tuberculosis or COVID-19 may not receive any benefit from this research.
What this research studies
This research investigates the impact of SARS-CoV-2 infection on tuberculosis (TB) in individuals already infected with Mycobacterium tuberculosis. By using a murine model, the study aims to characterize how COVID-19 superinfection alters TB immunity and leads to increased TB severity. Researchers will analyze immune responses and the spread of TB in the presence of COVID-19, providing insights into potential treatment strategies. The findings could help improve management of patients with both infections.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for patients suffering from both tuberculosis and COVID-19.
How similar studies have gone: Other research has shown that co-infections can complicate disease outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Talaat, Adel M — University of Wisconsin-Madison
- Study coordinator: Talaat, Adel M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.