Understanding how COVID-19 affects tuberculosis infections
Tuberculosis Immunopathogenesis During Superinfection with SARS-CoV2
This study looks at how getting COVID-19 affects people who already have tuberculosis, aiming to understand how the two infections interact and what that means for treatment, so we can better help those dealing with both illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11079637 on NIH RePORTER |
What this research studies
This research investigates the impact of SARS-CoV-2 infection on tuberculosis (TB) in individuals already infected with Mycobacterium tuberculosis. By using a murine model, the study aims to characterize how COVID-19 superinfection alters TB immunity and leads to increased TB severity. Researchers will analyze immune responses and the spread of TB in the presence of COVID-19, providing insights into potential treatment strategies. The findings could help improve management of patients with both infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are co-infected with Mycobacterium tuberculosis and SARS-CoV-2.
Not a fit: Patients who are not infected with either tuberculosis or COVID-19 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for patients suffering from both tuberculosis and COVID-19.
How similar studies have performed: Other research has shown that co-infections can complicate disease outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Talaat, Adel M — University of Wisconsin-Madison
- Study coordinator: Talaat, Adel M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.