Understanding how a specific molecule affects immune cells during sepsis
Official title: Methylglyoxal-induced macrophage metabolic dysregulation in sepsis
Funded at University of Maryland Baltimore · NIH-10738776 · Data updated 2026-11-12
This study is looking at how a specific immune cell called macrophages reacts during sepsis, a serious infection, and how a molecule called methylglyoxal affects these cells, with the hope of finding new ways to help patients recover better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | November 10, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $193,125 |
| NIH project number | 5R21AI174374-02 |
| Project ID | NIH-10738776 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sepsis or septic shock.
✕Less likely to help
Patients with non-infectious inflammatory conditions may not receive benefit from this research.
What this research studies
This research investigates the role of macrophages, a type of immune cell, in the body's response to sepsis, a severe infection that can lead to organ failure. The study focuses on how a molecule called methylglyoxal alters the metabolism of these macrophages, potentially leading to increased inflammation and tissue damage. By examining the changes in macrophage behavior and metabolism during sepsis, researchers aim to identify new therapeutic targets that could improve patient outcomes. The approach includes laboratory experiments that simulate sepsis conditions to observe macrophage responses.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage inflammation and improve survival rates in sepsis patients.
How similar studies have gone: Previous research has shown that targeting macrophage metabolism can lead to improved outcomes in inflammatory diseases, suggesting this approach may be promising.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Vogel, Stefanie N. — University of Maryland Baltimore
- Study coordinator: Vogel, Stefanie N.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.