Tracking how stem cells and their tiny vesicles move in a mouse model of brain bleed
Official title: Quantitative Dynamic Monitoring of MSCs and MSC-EVs in a Mouse Model of Intracerebral Hemorrhage
Funded at University of Miami School of Medicine · NIH-11380600 · Data updated 2026-11-12
A study in mice will map how stem cells and their extracellular vesicles distribute in the brain after an intracerebral hemorrhage to better understand how they could help repair the damaged brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 1, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $613,488 |
| NIH project number | 5R01EB036468-02 |
| Project ID | NIH-11380600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have suffered an intracerebral hemorrhage or are at risk for brain bleeds could benefit from later translation of improved MSC/MSC-EV therapies.
✕Less likely to help
Healthy individuals or patients with non-ICH brain conditions may not benefit from these findings.
What this research studies
This project uses a mouse model of intracerebral hemorrhage to visualize and quantify where mesenchymal stem cells and their extracellular vesicles go after administration. It aims to establish safe, precise tracking methods in living animals so we can compare cell- and vesicle-based therapies. The research focuses on how these therapies move through brain tissues, cross barriers, and potentially support nerve repair and immune regulation. Results could guide future treatments that are safer and more effective for people who have had a brain bleed.
Why it matters
Potential benefit: If successful, the work could lead to better-targeted cell-based or cell-free therapies to improve recovery after brain bleeds.
How similar studies have gone: Previous work suggests MSCs and MSC-EVs hold promise, but precise in vivo tracking and biodistribution in ICH are still being clarified.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Kuddannaya, Shreyas — University of Miami School of Medicine
- Study coordinator: Kuddannaya, Shreyas
Related research
Other NIH-funded projects on the same topics.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
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-
Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
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Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
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Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
-
Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
-
Silent brain injuries after brain bleed may predict dementia risk
A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.