Improving outcomes for children and young adults with relapsed B-cell leukemia after CAR T-cell therapy
Official title: Optimizing outcomes for children and young adults with relapse of B-cell acute lymphoblastic leukemia after CD19-targeted chimeric antigen receptor T-cell therapy
Funded at Children's Hosp of Philadelphia · NIH-11012281 · Data updated 2026-11-12
This study is looking for ways to help children and young adults with B-cell acute lymphoblastic leukemia who have had a relapse after a specific type of treatment, by testing new treatment strategies and better ways to track their health at the Children's Hospital of Philadelphia.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $180,885 |
| NIH project number | 5K08CA277013-03 |
| Project ID | NIH-11012281 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and young adults diagnosed with relapsed B-cell acute lymphoblastic leukemia who have previously undergone CAR T-cell therapy.
✕Less likely to help
Patients who are not diagnosed with B-cell acute lymphoblastic leukemia or who have not undergone CAR T-cell therapy may not benefit from this research.
What this research studies
This research focuses on enhancing treatment outcomes for children and young adults who experience a relapse of B-cell acute lymphoblastic leukemia after receiving CD19-targeted chimeric antigen receptor T-cell therapy. The project aims to develop and implement early phase clinical trials that utilize advanced epidemiological methods to better understand and improve patient responses to immunotherapy. Patients may benefit from innovative treatment strategies and improved monitoring of their health outcomes through this research. The work will be conducted at the Children's Hospital of Philadelphia, leveraging a multidisciplinary team of experts in pediatric oncology and immunotherapy.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options and improved survival rates for young patients with relapsed B-cell leukemia.
How similar studies have gone: Previous research has shown promising results with CAR T-cell therapy in treating B-cell malignancies, indicating a strong potential for success in this area.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Myers, Regina M — Children's Hosp of Philadelphia
- Study coordinator: Myers, Regina M
Related research
Other NIH-funded projects on the same topics.
-
Predicting relapse in children diagnosed with acute lymphoblastic leukemia
This study is looking to help doctors better predict if children with acute lymphoblastic leukemia might have a relapse by finding certain cells in their blood right at the time of diagnosis, so they can adjust treatments and improve outcomes for these kids.
-
Caregiver-led mobile tool to support healthy habits for kids treated for ALL
A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.
-
Genomics of childhood ALL across global populations
A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.
-
Genomics of childhood ALL across diverse populations
A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.
-
Combinatorial targeting for high-risk B-cell ALL treatment
A research effort at West Virginia University is exploring a combination therapy for adult B-cell acute lymphoblastic leukemia using targeted gene silencing and a small-molecule compound to improve treatment in patients.
-
Understanding why Latino children have a higher risk of childhood ALL
This project looks at why Latino children are more likely to develop acute lymphoblastic leukemia and whether genetic ancestry plays a role, with the goal of improving prevention and outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.