Predicting relapse in children diagnosed with acute lymphoblastic leukemia
Official title: Predicting Relapse at the Time of Diagnosis in Acute Lymphoblastic Leukemia
Funded at Stanford University · NIH-11047678 · Data updated 2026-11-12
This study is looking to help doctors better predict if children with acute lymphoblastic leukemia might have a relapse by finding certain cells in their blood right at the time of diagnosis, so they can adjust treatments and improve outcomes for these kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $513,054 |
| NIH project number | 5R01CA251858-05 |
| Project ID | NIH-11047678 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been newly diagnosed with acute lymphoblastic leukemia.
✕Less likely to help
Patients who are older than 11 years or those with other types of leukemia may not receive benefits from this research.
What this research studies
This research focuses on improving the prediction of relapse in children diagnosed with acute lymphoblastic leukemia (ALL). By utilizing a cutting-edge single-cell proteomic approach, the study aims to identify specific pre-B cells that indicate a higher risk of relapse at the time of diagnosis. This method is designed to provide immediate and actionable insights, allowing for timely adjustments in treatment strategies. The goal is to enhance the accuracy of relapse predictions and ultimately reduce the incidence of relapse in affected children.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates for children with acute lymphoblastic leukemia by enabling earlier and more effective interventions.
How similar studies have gone: This approach is innovative and has shown promise in preliminary findings, indicating a potential breakthrough in relapse prediction for acute lymphoblastic leukemia.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Davis, Kara Lynn — Stanford University
- Study coordinator: Davis, Kara Lynn
Related research
Other NIH-funded projects on the same topics.
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Improving outcomes for children and young adults with relapsed B-cell leukemia after CAR T-cell therapy
This study is looking for ways to help children and young adults with B-cell acute lymphoblastic leukemia who have had a relapse after a specific type of treatment, by testing new treatment strategies and better ways to track their health at the Children's Hospital of Philadelphia.
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Caregiver-led mobile tool to support healthy habits for kids treated for ALL
A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.
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Genomics of childhood ALL across global populations
A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.
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Genomics of childhood ALL across diverse populations
A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.
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Combinatorial targeting for high-risk B-cell ALL treatment
A research effort at West Virginia University is exploring a combination therapy for adult B-cell acute lymphoblastic leukemia using targeted gene silencing and a small-molecule compound to improve treatment in patients.
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Understanding why Latino children have a higher risk of childhood ALL
This project looks at why Latino children are more likely to develop acute lymphoblastic leukemia and whether genetic ancestry plays a role, with the goal of improving prevention and outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.