Understanding genes that affect stem cell growth and relapse in Acute Myeloid Leukemia
Genes regulating stem and progenitor cell expansion and relapse in Acute Myeloid Leukemia
This study is looking at how certain genes affect the growth of blood cells in people with Acute Myeloid Leukemia (AML) to understand why some patients might experience a return of the disease after treatment, with the hope of finding better ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11117923 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence the growth of stem and progenitor cells in patients with Acute Myeloid Leukemia (AML). It aims to identify the cellular and molecular mechanisms that contribute to the persistence of leukemic cells after treatment, which can lead to relapse. By studying mutations in long-term hematopoietic stem cells, the research seeks to uncover how these cells can gain competitive advantages and ultimately cause the disease to return. Patients may benefit from insights that could lead to improved treatment strategies and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Acute Myeloid Leukemia, particularly those who have undergone standard chemotherapy treatments.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with Acute Myeloid Leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies that reduce the risk of relapse in AML patients.
How similar studies have performed: Previous research has shown promise in understanding genetic mutations in leukemia, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Malek, Sami Nimer — University of Michigan at Ann Arbor
- Study coordinator: Malek, Sami Nimer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.