Targeting silent brain infarcts to improve neurologic outcomes in iTTP

Who could benefit from this research

What this research studies

People living with iTTP may have silent brain injuries that aren’t obvious yet can affect thinking and increase stroke risk. This project will follow several patient groups across three major medical centers to map how these silent injuries develop over time, whether they predict future strokes, and how we might prevent them. Researchers will use MRI to identify silent cerebral infarctions and correlate findings with cognitive function and stroke risk. The study builds on prior work and aims to translate observations into better monitoring and prevention for patients with iTTP.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Chaturvedi, Shruti — Johns Hopkins University
• Study coordinator: Chaturvedi, Shruti

Related research

Other NIH-funded projects on the same topics.

• Targeting hidden brain injuries in iTTP to improve long-term brain health

  A researcher aims to find out how silent brain injuries in people with immune thrombotic thrombocytopenic purpura (iTTP) happen, how they affect thinking and stroke risk, and how to prevent them.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11638596

• Preventing silent brain infarcts in people who survived immune TTP

  This project looks at whether finding and preventing small, symptom-free brain infarcts can protect thinking and lower stroke risk in adults who survived immune thrombotic thrombocytopenic purpura (iTTP).

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11177712

• Investigating how type I interferon helps restore blood-brain barrier function after a stroke

  This study is looking at how a certain signaling process in the body can help repair the brain's protective barrier after a stroke, with the hope that the findings will lead to new ways to support recovery for stroke patients.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11003276

• Improving brain health in patients with immune thrombotic thrombocytopenic purpura

  This study is looking at how surviving a rare blood disorder called immune thrombotic thrombocytopenic purpura (iTTP) might affect brain health over time, especially focusing on hidden brain injuries that can happen without any noticeable symptoms, to help find ways to keep your brain healthy after treatment.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10816664

• Erlangen Stroke Registry: A long-running look at stroke in a German community

  This registry is testing how stroke cases are collected and followed over time in Erlangen to understand how many people are affected and how care evolves.

  Recruiting at 3 sites University of Erlangen-Nürnberg Medical School · Erlangen and 2 other locations · NCT07771335

• Early Identification of BAD-related Stroke in Adults

  This study tests how well a multisource AI diagnostic approach can identify BAD-related stroke among adults with acute ischemic stroke within a week of onset.

  Recruiting at 11 sites Peking Union Medical College Hospital · Beijing and 10 other locations · NCT07693816

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.