Preventing silent brain infarcts in people who survived immune TTP
Targeting silent cerebral infarction to improve long-term neurologic outcomes in immune thrombotic thrombocytopenic purpura (iTTP)
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11177712
This project looks at whether finding and preventing small, symptom-free brain infarcts can protect thinking and lower stroke risk in adults who survived immune thrombotic thrombocytopenic purpura (iTTP).
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11177712 on ClinicalTrials.gov |
What this research studies
If you join, researchers at three U.S. centers will follow adults who have survived iTTP and use brain MRI scans to look for silent cerebral infarcts (areas of brain injury without obvious symptoms). They will compare when these silent infarcts happen—during recovery or only after acute episodes—and link MRI findings to cognitive testing and later stroke events. The study builds on a single-center finding that half of iTTP survivors had silent infarcts and will collect data across Johns Hopkins, Ohio State, and the University of Minnesota to confirm those results. The team will also explore factors that might prevent these silent injuries and their long-term effects on thinking and stroke risk.
Who could benefit from this research
Good fit: Ideal candidates are adults with a history of immune TTP who can attend follow-up visits and undergo brain MRI and cognitive testing at one of the participating centers.
Not a fit: People without a history of iTTP or those unable to travel to the study centers or undergo MRI are unlikely to benefit directly from this study.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection and new ways to prevent silent brain injuries, lowering the risk of cognitive decline and future strokes for iTTP survivors.
How similar studies have performed: A prior single-center study found a high rate of silent infarcts and links to cognitive problems in iTTP survivors, but multi-center confirmation and prevention strategies remain largely untested.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHATURVEDI, SHRUTI — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CHATURVEDI, SHRUTI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Vascular Disorders