Preventing silent brain infarcts in people who survived immune TTP
Official title: Targeting silent cerebral infarction to improve long-term neurologic outcomes in immune thrombotic thrombocytopenic purpura (iTTP)
Funded at Johns Hopkins University · NIH-11177712 · Data updated 2026-11-12
This project looks at whether finding and preventing small, symptom-free brain infarcts can protect thinking and lower stroke risk in adults who survived immune thrombotic thrombocytopenic purpura (iTTP).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 27, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $399,841 |
| NIH project number | 5R00HL172303-02 |
| Project ID | NIH-11177712 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with a history of immune TTP who can attend follow-up visits and undergo brain MRI and cognitive testing at one of the participating centers.
✕Less likely to help
People without a history of iTTP or those unable to travel to the study centers or undergo MRI are unlikely to benefit directly from this study.
What this research studies
If you join, researchers at three U.S. centers will follow adults who have survived iTTP and use brain MRI scans to look for silent cerebral infarcts (areas of brain injury without obvious symptoms). They will compare when these silent infarcts happen—during recovery or only after acute episodes—and link MRI findings to cognitive testing and later stroke events. The study builds on a single-center finding that half of iTTP survivors had silent infarcts and will collect data across Johns Hopkins, Ohio State, and the University of Minnesota to confirm those results. The team will also explore factors that might prevent these silent injuries and their long-term effects on thinking and stroke risk.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection and new ways to prevent silent brain injuries, lowering the risk of cognitive decline and future strokes for iTTP survivors.
How similar studies have gone: A prior single-center study found a high rate of silent infarcts and links to cognitive problems in iTTP survivors, but multi-center confirmation and prevention strategies remain largely untested.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Chaturvedi, Shruti — Johns Hopkins University
- Study coordinator: Chaturvedi, Shruti
Related research
Other NIH-funded projects on the same topics.
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Targeting hidden brain injuries in iTTP to improve long-term brain health
A researcher aims to find out how silent brain injuries in people with immune thrombotic thrombocytopenic purpura (iTTP) happen, how they affect thinking and stroke risk, and how to prevent them.
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Targeting silent brain infarcts to improve neurologic outcomes in iTTP
A multi-center study looks at hidden brain injuries in adults with immune thrombotic thrombocytopenic purpura (iTTP) and what it means for their long-term brain health.
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Improving brain health in patients with immune thrombotic thrombocytopenic purpura
This study is looking at how surviving a rare blood disorder called immune thrombotic thrombocytopenic purpura (iTTP) might affect brain health over time, especially focusing on hidden brain injuries that can happen without any noticeable symptoms, to help find ways to keep your brain healthy after treatment.
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Erlangen Stroke Registry: A long-running look at stroke in a German community
This registry is testing how stroke cases are collected and followed over time in Erlangen to understand how many people are affected and how care evolves.
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Early Identification of BAD-related Stroke in Adults
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.