Investigating how type I interferon helps restore blood-brain barrier function after a stroke
Official title: Type I Interferon Mediated Restoration of Brain Endothelial Cell Function after Cerebral Infarction
Funded at Columbia University Health Sciences · NIH-11003276 · Data updated 2026-11-12
This study is looking at how a certain signaling process in the body can help repair the brain's protective barrier after a stroke, with the hope that the findings will lead to new ways to support recovery for stroke patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 15, 2023 |
| Project end | March 14, 2025 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS130983-03 |
| Project ID | NIH-11003276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a cerebral infarction or stroke.
✕Less likely to help
Patients who have not had a stroke or have other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding how type I interferon signaling can aid in the restoration of blood-brain barrier (BBB) function following a cerebral infarction, or stroke. The study examines the mechanisms of vascular remodeling and how inflammation influences tissue repair in the brain. By utilizing advanced imaging techniques and analyzing cellular responses, the research aims to uncover the role of specific signaling pathways in promoting recovery after ischemic injury. Patients may benefit from insights that could lead to new therapeutic strategies for stroke recovery.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance recovery and repair of brain function after a stroke.
How similar studies have gone: Previous research has shown promising results in understanding the role of type I interferon in vascular repair in other diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Tuohy, Mary Claire — Columbia University Health Sciences
- Study coordinator: Tuohy, Mary Claire
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.