Investigating how type I interferon helps restore blood-brain barrier function after a stroke
Type I Interferon Mediated Restoration of Brain Endothelial Cell Function after Cerebral Infarction
This study is looking at how a certain signaling process in the body can help repair the brain's protective barrier after a stroke, with the hope that the findings will lead to new ways to support recovery for stroke patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11003276 on NIH RePORTER |
What this research studies
This research focuses on understanding how type I interferon signaling can aid in the restoration of blood-brain barrier (BBB) function following a cerebral infarction, or stroke. The study examines the mechanisms of vascular remodeling and how inflammation influences tissue repair in the brain. By utilizing advanced imaging techniques and analyzing cellular responses, the research aims to uncover the role of specific signaling pathways in promoting recovery after ischemic injury. Patients may benefit from insights that could lead to new therapeutic strategies for stroke recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a cerebral infarction or stroke.
Not a fit: Patients who have not had a stroke or have other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance recovery and repair of brain function after a stroke.
How similar studies have performed: Previous research has shown promising results in understanding the role of type I interferon in vascular repair in other diseases, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Tuohy, Mary Claire — Columbia University Health Sciences
- Study coordinator: Tuohy, Mary Claire
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.