Targeting hidden brain injuries in iTTP to improve long-term brain health
Official title: Targeting silent cerebral infarction to improve long-term neurologic outcomes in immune thrombotic thrombocytopenic purpura (iTTP)
Funded at Johns Hopkins University · NIH-11638596 · Data updated 2026-11-12
A researcher aims to find out how silent brain injuries in people with immune thrombotic thrombocytopenic purpura (iTTP) happen, how they affect thinking and stroke risk, and how to prevent them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 27, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $108,850 |
| NIH project number | 3R00HL172303-03S1 |
| Project ID | NIH-11638596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of iTTP who have or had silent brain injuries or are at risk for them, enrolled across three participating centers.
✕Less likely to help
Patients without iTTP or those not meeting clinical criteria for participation may not benefit from this study.
What this research studies
People living with iTTP can have unseen brain injuries that may affect memory and thinking and raise stroke risk. This project will follow iTTP patients across three centers to map when these silent injuries occur and whether they predict future stroke. The study will use brain scans and cognitive assessments to understand the progression and potential prevention strategies. Results could guide better monitoring and therapies to protect brain health in iTTP survivors.
Why it matters
Potential benefit: If successful, the work could reduce cognitive problems and stroke risk for iTTP patients by guiding monitoring and prevention strategies.
How similar studies have gone: Prior work showed a high rate of silent brain infarcts in iTTP survivors, but multicenter longitudinal data are needed to guide prevention.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Chaturvedi, Shruti — Johns Hopkins University
- Study coordinator: Chaturvedi, Shruti
Related research
Other NIH-funded projects on the same topics.
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Targeting silent brain infarcts to improve neurologic outcomes in iTTP
A multi-center study looks at hidden brain injuries in adults with immune thrombotic thrombocytopenic purpura (iTTP) and what it means for their long-term brain health.
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Preventing silent brain infarcts in people who survived immune TTP
This project looks at whether finding and preventing small, symptom-free brain infarcts can protect thinking and lower stroke risk in adults who survived immune thrombotic thrombocytopenic purpura (iTTP).
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Investigating how type I interferon helps restore blood-brain barrier function after a stroke
This study is looking at how a certain signaling process in the body can help repair the brain's protective barrier after a stroke, with the hope that the findings will lead to new ways to support recovery for stroke patients.
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Improving brain health in patients with immune thrombotic thrombocytopenic purpura
This study is looking at how surviving a rare blood disorder called immune thrombotic thrombocytopenic purpura (iTTP) might affect brain health over time, especially focusing on hidden brain injuries that can happen without any noticeable symptoms, to help find ways to keep your brain healthy after treatment.
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Erlangen Stroke Registry: A long-running look at stroke in a German community
This registry is testing how stroke cases are collected and followed over time in Erlangen to understand how many people are affected and how care evolves.
-
Early Identification of BAD-related Stroke in Adults
This study tests how well a multisource AI diagnostic approach can identify BAD-related stroke among adults with acute ischemic stroke within a week of onset.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.