Improving brain health in patients with immune thrombotic thrombocytopenic purpura
Targeting silent cerebral infarction to improve long-term neurologic outcomes in immune thrombotic thrombocytopenic purpura (iTTP)
This study is looking at how surviving a rare blood disorder called immune thrombotic thrombocytopenic purpura (iTTP) might affect brain health over time, especially focusing on hidden brain injuries that can happen without any noticeable symptoms, to help find ways to keep your brain healthy after treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10816664 on NIH RePORTER |
What this research studies
This research investigates the long-term neurological outcomes in patients who have survived immune thrombotic thrombocytopenic purpura (iTTP), a rare blood disorder. It focuses on understanding silent cerebral infarctions, which are brain injuries that occur without obvious symptoms, and their potential impact on cognitive function and stroke risk. The study will involve multiple clinical sites and aims to determine whether these brain injuries occur during remission or only after acute episodes of iTTP. By identifying the incidence and risk factors for these silent infarctions, the research seeks to develop strategies to prevent them and improve overall brain health in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have been diagnosed with immune thrombotic thrombocytopenic purpura.
Not a fit: Patients who do not have a diagnosis of immune thrombotic thrombocytopenic purpura are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for cognitive impairment and stroke in iTTP survivors.
How similar studies have performed: Previous research has shown a high prevalence of silent cerebral infarctions in iTTP survivors, indicating that this area of investigation is both relevant and necessary.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Chaturvedi, Shruti — Johns Hopkins University
- Study coordinator: Chaturvedi, Shruti
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.