Targeting endothelial epsins to help the heart heal after a heart attack
Official title: Targeting Endothelial Epsins to Ameliorate Myocardial Ischemia
Funded at Boston Children's Hospital · NIH-11380819 · Data updated 2026-11-12
Researchers are studying a protein in blood vessels to find ways to improve blood flow and heart repair after a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 8, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $760,411 |
| NIH project number | 5R01HL174928-03 |
| Project ID | NIH-11380819 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21+ with or at risk for acute myocardial infarction or coronary artery disease may be relevant for future trials or related biomarker studies.
✕Less likely to help
Healthy individuals without heart disease or risk factors are unlikely to benefit directly from this specific research.
What this research studies
This project explores how endothelial epsins influence blood vessel responses during myocardial ischemia and aims to identify molecular targets that could promote heart repair. By examining the role of epsins in endothelial cells, the study seeks to unveil pathways that enhance blood flow and tissue regeneration after acute coronary events. The work is conducted at Boston Children's Hospital under the direction of Hong Chen, focusing on mechanisms that could translate into new therapies for patients who have suffered or are at risk of heart attacks.
Why it matters
Potential benefit: If successful, the research could lead to new treatments that improve heart blood flow and recovery after a heart attack.
How similar studies have gone: Previous studies on endothelial regulation and vascular repair have shown promise, but this project investigates a novel target (epsins) in the context of myocardial ischemia.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Chen, Hong — Boston Children's Hospital
- Study coordinator: Chen, Hong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.