Role of miR98 in heart injury during late pregnancy
Official title: Role of miR98 in Myocardial Ischemia Reperfusion Injury in Pregnancy
Funded at University of California Los Angeles · NIH-11367676 · Data updated 2026-11-12
A study in pregnant people or models will look at how a tiny molecule called miR98 affects heart injury after a heart attack during the third trimester.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 15, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $531,794 |
| NIH project number | 1R01HL181340-01A1 |
| Project ID | NIH-11367676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants would be adults in the third trimester of pregnancy or, where applicable, patient samples and models that reflect late-pregnancy heart biology.
✕Less likely to help
Non-pregnant individuals or those without heart injury may not directly benefit from these findings.
What this research studies
This research explores why the heart is more vulnerable to injury during late pregnancy and whether miR98 helps or worsens that injury. It uses data from human adults in the context of pregnancy and may include pregnancy-specific heart biology, along with animal or cellular models to study mechanisms. The team will examine how miR98 behaves in heart cells and immune cells during ischemia-reperfusion injury and how hormones like estradiol influence it. Results could point toward new ideas for protecting the pregnant heart from damage during a heart attack.
Why it matters
Potential benefit: If successful, findings could lead to strategies to reduce heart damage in late-pregnancy patients who have a heart attack.
How similar studies have gone: Prior data in animals and humans suggest a link between miR98 and heart injury, but pregnancy-specific effects are still being explored.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Eghbali, Mansoureh — University of California Los Angeles
- Study coordinator: Eghbali, Mansoureh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.