Exploring the use of a protein to improve heart recovery after injury.
Official title: Investigation of therapeutic potential of exogenous ubiquitin following myocardial ischemia/reperfusion injury
Funded at James H Quillen VA Medical Center · NIH-11092679 · Data updated 2026-11-12
This study is looking at how a small protein called ubiquitin might help the heart heal better after it's been damaged from not getting enough blood, like during a heart attack, by reducing inflammation and scarring.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James H Quillen VA Medical Center NIH-funded |
| Lab location | 1 site (Mountain Home, United States) |
| Project start | April 1, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX004045-06 |
| Project ID | NIH-11092679 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have suffered from myocardial infarction or are at risk of ischemic heart disease.
✕Less likely to help
Patients with non-cardiac related health issues or those who have not experienced myocardial ischemia may not benefit from this research.
What this research studies
This research investigates how exogenous ubiquitin, a small protein, can help the heart recover after it has been damaged due to a lack of blood flow, known as myocardial ischemia/reperfusion injury. The study focuses on understanding how ubiquitin can reduce inflammation and scar formation in the heart, which are critical factors in the healing process after a heart attack. By using both laboratory models and animal studies, researchers aim to demonstrate that treatment with ubiquitin can improve heart function and reduce damage following such injuries.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and heart function for patients who have experienced heart attacks.
How similar studies have gone: Previous research has shown promising results with similar therapeutic approaches targeting cardiac inflammation and remodeling, indicating potential for success in this area.
Where this research is happening
-
James H Quillen VA Medical Center
Mountain Home, United States Active
Researchers
- Principal investigator: Singh, Krishna — James H Quillen VA Medical Center
- Study coordinator: Singh, Krishna
Related research
Other NIH-funded projects on the same topics.
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Targeting endothelial epsins to help the heart heal after a heart attack
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Role of miR98 in heart injury during late pregnancy
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Role of LonP1 in protecting the heart from ischemia-reperfusion injury
A study to see if boosting a mitochondrial protein called LonP1 can reduce heart damage after a blocked artery is opened in people who have a heart attack.
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Helping the heart recover after a heart attack by targeting blood vessel cell proteins (epsins)
This project tests whether blocking a protein called epsins in the cells that line blood vessels can help the heart heal better after a heart attack.
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How metabolic syndrome harms heart blood vessels
The team is testing whether common diabetes drugs can help blood vessels grow and protect the heart in people with metabolic syndrome and diabetes by studying a pig model that mimics patients.
-
Investigating how a mitochondrial protein protects the heart during injury from blood flow restoration
This study is looking at a protein called LonP1 that might help protect heart cells from damage when blood flow returns after a heart attack, with the hope of finding new treatments to help your heart heal better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.