Exploring the use of a protein to improve heart recovery after injury.
Investigation of therapeutic potential of exogenous ubiquitin following myocardial ischemia/reperfusion injury
This study is looking at how a small protein called ubiquitin might help the heart heal better after it's been damaged from not getting enough blood, like during a heart attack, by reducing inflammation and scarring.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James H Quillen VA Medical Center NIH-funded |
| Lab location | 1 site (Mountain Home, United States) |
| Project ID | NIH-11092679 on NIH RePORTER |
What this research studies
This research investigates how exogenous ubiquitin, a small protein, can help the heart recover after it has been damaged due to a lack of blood flow, known as myocardial ischemia/reperfusion injury. The study focuses on understanding how ubiquitin can reduce inflammation and scar formation in the heart, which are critical factors in the healing process after a heart attack. By using both laboratory models and animal studies, researchers aim to demonstrate that treatment with ubiquitin can improve heart function and reduce damage following such injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have suffered from myocardial infarction or are at risk of ischemic heart disease.
Not a fit: Patients with non-cardiac related health issues or those who have not experienced myocardial ischemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and heart function for patients who have experienced heart attacks.
How similar studies have performed: Previous research has shown promising results with similar therapeutic approaches targeting cardiac inflammation and remodeling, indicating potential for success in this area.
Where this research is happening
Mountain Home, United States
- James H Quillen VA Medical Center — Mountain Home, United States (Active)
Researchers
- Principal investigator: Singh, Krishna — James H Quillen VA Medical Center
- Study coordinator: Singh, Krishna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.