Investigating how a mitochondrial protein protects the heart during injury from blood flow restoration
Role of the mitochondrial LonP1 in myocardial ischemia and reperfusion injury protection
['FUNDING_R01'] · WEST VIRGINIA UNIVERSITY · NIH-11077313
This study is looking at a protein called LonP1 that might help protect heart cells from damage when blood flow returns after a heart attack, with the hope of finding new treatments to help your heart heal better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEST VIRGINIA UNIVERSITY (nih funded) |
| Locations | 1 site (MORGANTOWN, UNITED STATES) |
| Trial ID | NIH-11077313 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a specific mitochondrial protein, LonP1, can help protect heart cells from damage caused by the restoration of blood flow after a heart attack. By studying the role of LonP1 in the early stages of ischemia-reperfusion injury, researchers aim to identify new therapeutic targets that could limit heart damage. The approach involves examining the molecular mechanisms of how LonP1 mitigates oxidative stress and promotes heart cell survival during critical periods following a heart attack. Patients may benefit from potential new treatments that enhance LonP1 function to improve heart recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction or are at high risk for heart attacks.
Not a fit: Patients with chronic heart conditions unrelated to ischemia-reperfusion injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce heart damage and improve recovery after heart attacks.
How similar studies have performed: Previous research has shown promising results in using mitochondrial proteins for cardioprotection, indicating that this approach has potential for success.
Where this research is happening
MORGANTOWN, UNITED STATES
- WEST VIRGINIA UNIVERSITY — MORGANTOWN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUNDARARAJAN, VENKATESH — WEST VIRGINIA UNIVERSITY
- Study coordinator: SUNDARARAJAN, VENKATESH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.