STOP-SCD-VTE: How and when blood thinners are used for adults with sickle cell disease and blood clots
Official title: STOP-SCD-VTE: STudy of anticoagulation Outcomes and Practice patterns for patients with Sickle Cell Disease and Venous ThromboEmbolism
Funded at Boston University Medical Campus · NIH-11297560 · Data updated 2026-11-12
A real-world study of how doctors use long-term blood thinners in adults with sickle cell disease who have had a venous clot, and whether different medicines or patterns affect outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 15, 2026 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,668,912 |
| NIH project number | 1R01HL179187-01A1 |
| Project ID | NIH-11297560 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with sickle cell disease who have experienced a first venous thromboembolism and are starting or on long-term anticoagulation.
✕Less likely to help
Patients not treated for venous thromboembolism or those without sickle cell disease may not directly benefit.
What this research studies
This project looks at adults with sickle cell disease who suffer a first blood clot to see how long-term anticoagulation is actually used in everyday care. Researchers will analyze data from several large patient registries to identify variation in treatment and potential disparities. They will compare common blood thinners and examine whether following newer guidelines could reduce recurrent clots and bleeding risks. The goal is to better align real-world practice with evidence to improve safety and effectiveness for patients like you.
Why it matters
Potential benefit: If successful, the findings could guide doctors on the best long-term anticoagulation choices for sickle cell patients with clots and help reduce recurrent events and bleeding risks.
How similar studies have gone: Previous work suggests variability in anticoagulation practices; this study will clarify real-world patterns and outcomes.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Klings, Elizabeth S — Boston University Medical Campus
- Study coordinator: Klings, Elizabeth S
Related research
Other NIH-funded projects on the same topics.
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Understanding blood clot risks in children with sickle cell disease
This study is looking at what might cause blood clots in children with sickle cell disease, so we can find better ways to prevent and treat these clots and help keep kids healthier.
-
Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients
A large study will test whether taking rosuvastatin every day for a year can lower the chance of dangerous blood clots in people with cancer, without raising the risk of bleeding.
-
Optimal use of blood thinners for venous clots in people with cirrhosis
This grant hopes to figure out the safest and most effective way to use oral anticoagulants for adults with cirrhosis who develop venous clots.
-
PET/CT imaging to detect chemotherapy-related vascular harm in young cancer patients
A non-invasive PET/CT scan method using standard care imaging is being tested to identify which pediatric and young adult cancer patients are at higher risk of blood clots from chemotherapy.
-
Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients
A large clinical trial will test whether taking rosuvastatin daily for a year helps prevent dangerous blood clots in people with newly diagnosed or relapsed cancer who aren’t already getting anticoagulants.
-
BCOR's role in blood clot risk and liver genetics
A Johns Hopkins-led study is exploring how a human gene, BCOR, may control liver-produced clotting factors to influence venous blood clots.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.