Understanding blood clot risks in children with sickle cell disease
Official title: Clinical and Molecular based prognostic factors for Venous Thromboembolism (VTE) in Children with Sickle Cell Disease
Funded at Johns Hopkins University · NIH-10907804 · Data updated 2026-11-12
This study is looking at what might cause blood clots in children with sickle cell disease, so we can find better ways to prevent and treat these clots and help keep kids healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $196,867 |
| NIH project number | 5K23HL165043-02 |
| Project ID | NIH-10907804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with sickle cell disease, particularly those who have experienced or are at risk for venous thromboembolism.
✕Less likely to help
Patients who do not have sickle cell disease or those over the age of 21 may not benefit from this research.
What this research studies
This research investigates the risk factors for blood clots, known as venous thromboembolism (VTE), in children suffering from sickle cell disease (SCD). It aims to identify both clinical and molecular markers that contribute to the development of VTE in this vulnerable population. By analyzing data from multiple centers and collecting biological samples, the study seeks to uncover important insights that could lead to better prevention and treatment strategies. The findings could help healthcare providers better manage the risks associated with SCD in pediatric patients.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and management of blood clot risks in children with sickle cell disease, enhancing their overall health outcomes.
How similar studies have gone: While there has been limited research specifically on VTE in pediatric sickle cell disease, similar studies in other populations have shown promising results in identifying risk factors and improving patient outcomes.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Betensky, Marisol — Johns Hopkins University
- Study coordinator: Betensky, Marisol
Related research
Other NIH-funded projects on the same topics.
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STOP-SCD-VTE: How and when blood thinners are used for adults with sickle cell disease and blood clots
A real-world study of how doctors use long-term blood thinners in adults with sickle cell disease who have had a venous clot, and whether different medicines or patterns affect outcomes.
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Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients
A large study will test whether taking rosuvastatin every day for a year can lower the chance of dangerous blood clots in people with cancer, without raising the risk of bleeding.
-
Optimal use of blood thinners for venous clots in people with cirrhosis
This grant hopes to figure out the safest and most effective way to use oral anticoagulants for adults with cirrhosis who develop venous clots.
-
PET/CT imaging to detect chemotherapy-related vascular harm in young cancer patients
A non-invasive PET/CT scan method using standard care imaging is being tested to identify which pediatric and young adult cancer patients are at higher risk of blood clots from chemotherapy.
-
Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients
A large clinical trial will test whether taking rosuvastatin daily for a year helps prevent dangerous blood clots in people with newly diagnosed or relapsed cancer who aren’t already getting anticoagulants.
-
BCOR's role in blood clot risk and liver genetics
A Johns Hopkins-led study is exploring how a human gene, BCOR, may control liver-produced clotting factors to influence venous blood clots.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.