Statin use in brain bleed patients MRI study in SATURN MRI ancillary
Official title: StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
Funded at Beth Israel Deaconess Medical Center · NIH-11400999 · Data updated 2026-11-12
A large MRI-focused study will look at whether continuing statin therapy after a brain bleed helps or harms patients who had lobar intracerebral hemorrhage.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $792,665 |
| NIH project number | 5U01NS120871-03 |
| Project ID | NIH-11400999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with lobar intracerebral hemorrhage who are on statin therapy and eligible for SATURN, across participating sites.
✕Less likely to help
Patients not meeting SATURN eligibility or not on statins at baseline may not be part of this ancillary MRI study.
What this research studies
This ancillary MRI study pairs with the SATURN trial to enroll participants who had lobar ICH and are already on statins. Participants will have standardized brain MRIs at baseline and 24 months to look for small vessel disease markers like microbleeds and cortical siderosis. The goal is to see if continuing statins affects the development or progression of these MRI markers and how that relates to future brain health and function. Findings could help doctors decide which patients with lobar ICH should stay on statins long-term.
Why it matters
Potential benefit: If successful, results could guide clinicians on statin use after lobar ICH to balance recurrence risk and cardiovascular protection.
How similar studies have gone: Similar MRI studies in stroke patients have shown that imaging markers can relate to outcomes, but this specific statin-ICH MRI question is exploratory.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
Related research
Other NIH-funded projects on the same topics.
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Wearable tech to track blood loss during childbirth
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SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.
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Statin use after brain bleed MRI study in ICH patients (SATURN MRI) Ancillary Study
This project tests whether continuing or stopping statin therapy after an intracerebral hemorrhage affects brain changes seen on MRI and related health outcomes in people with lobar ICH.
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Statin use after brain bleed: SATURN MRI ancillary study
This project tests whether continuing statin medicines after a brain bleed (lobar intracerebral hemorrhage) affects new brain blood vessel findings and long-term health.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.