NIH-funded research Career grant

SPOT-IT: Cancer sepsis prediction in the hospital using smart technology

Official title: SPOT-IT: Sepsis Prediction in Oncology Through Implementation Science and Technology

Funded at Oregon Health & Science University · NIH-11326241 · Data updated 2026-11-12

A physician-scientist is developing an AI tool that uses hospital electronic health data to spot sepsis早 in people with cancer so doctors can act sooner.

More Sepsis research and trials

Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionOregon Health & Science University
NIH-funded
Lab location1 site (Portland, United States)
Project startJune 7, 2024
Project endMay 31, 2029
Funding year2026
Award (this year)$283,821
NIH project number5K08CA270383-03
Project IDNIH-11326241 on NIH RePORTER

Who could benefit from this research

Could help

Cancer patients in hospital settings who are at risk for sepsis and would be served by improved early warning tools.

Less likely to help

Patients not experiencing sepsis or not in hospital settings may not directly benefit.

What this research studies

This grant supports training a clinician-scientist to create an oncology-specific sepsis prediction model using machine learning and to design usable implementation strategies for real-world hospital settings. The work combines data analysis of electronic health records with human-centered design to ensure the tool fits into clinicians’ workflows. If successful, it could lead to earlier recognition of sepsis in cancer patients and faster, life-saving treatment. The project emphasizes practical deployment in hospital care delivery and aims to build skills for independent research leadership. The focus remains on improving outcomes for cancer patients who are at higher risk of deadly sepsis.

Why it matters

Potential benefit: Could help clinicians recognize sepsis earlier in cancer patients, potentially reducing deaths and complications.

How similar studies have gone: Preliminary work and prior sepsis prediction efforts show promise, but cancer-specific models and implementation strategies are still developing.

Where this research is happening

  • Oregon Health & Science University
    Portland, United States
    Active

Researchers

  • Principal investigator: Lyons, Patrick G — Oregon Health & Science University
  • Study coordinator: Lyons, Patrick G

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.