SPOT-IT: Cancer sepsis prediction in the hospital using smart technology
Official title: SPOT-IT: Sepsis Prediction in Oncology Through Implementation Science and Technology
Funded at Oregon Health & Science University · NIH-11326241 · Data updated 2026-11-12
A physician-scientist is developing an AI tool that uses hospital electronic health data to spot sepsis早 in people with cancer so doctors can act sooner.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 7, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $283,821 |
| NIH project number | 5K08CA270383-03 |
| Project ID | NIH-11326241 on NIH RePORTER |
Who could benefit from this research
✓Could help
Cancer patients in hospital settings who are at risk for sepsis and would be served by improved early warning tools.
✕Less likely to help
Patients not experiencing sepsis or not in hospital settings may not directly benefit.
What this research studies
This grant supports training a clinician-scientist to create an oncology-specific sepsis prediction model using machine learning and to design usable implementation strategies for real-world hospital settings. The work combines data analysis of electronic health records with human-centered design to ensure the tool fits into clinicians’ workflows. If successful, it could lead to earlier recognition of sepsis in cancer patients and faster, life-saving treatment. The project emphasizes practical deployment in hospital care delivery and aims to build skills for independent research leadership. The focus remains on improving outcomes for cancer patients who are at higher risk of deadly sepsis.
Why it matters
Potential benefit: Could help clinicians recognize sepsis earlier in cancer patients, potentially reducing deaths and complications.
How similar studies have gone: Preliminary work and prior sepsis prediction efforts show promise, but cancer-specific models and implementation strategies are still developing.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Lyons, Patrick G — Oregon Health & Science University
- Study coordinator: Lyons, Patrick G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.