Sirtuin-Driven Control of TB and HIV Interactions in Macrophages
Official title: Sirtuin -Dependent Regulation of Tuberculosis and HIV Interactions in Macrophages
Funded at Methodist Hospital Research Institute · NIH-11365877 · Data updated 2026-11-12
Aims to find new ways to slow or stop both tuberculosis and HIV by targeting cellular enzymes in immune cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,236,275 |
| NIH project number | 5R01AI184551-03 |
| Project ID | NIH-11365877 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals with HIV and/or TB coinfection or those at risk for these infections, depending on future trial design and approvals.
✕Less likely to help
People without HIV or TB, or those not fitting the trial criteria, may not directly benefit.
What this research studies
This project studies how a family of enzymes called Sirtuins changes during TB and HIV infections in human macrophages, and whether drugs that target these enzymes can help control both pathogens. Researchers will look at early infection stages to see how Sirtuins influence HIV and TB growth and identify epigenetic targets. They will test a combined immunochemotherapy approach that uses Sirtuin-targeting drugs with TB and HIV therapies to try to eradicate both infections in macrophages and humanized mouse models. The work progresses from cell culture to animal studies to explore a potential new treatment strategy for coinfection.
Why it matters
Potential benefit: If successful, it could lead to a novel treatment strategy that helps people with HIV/TB coinfection by targeting shared pathways in immune cells.
How similar studies have gone: Previous work has shown that modulating Sirtuins can affect pathogen replication in cell and animal models, but this specific coinfection approach is a novel direction with early-stage data.
Where this research is happening
-
Methodist Hospital Research Institute
Houston, United States Active
Researchers
- Principal investigator: Jagannath, Chinnaswamy — Methodist Hospital Research Institute
- Study coordinator: Jagannath, Chinnaswamy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.