Sponsor or institution
Clinical trials and research at Methodist Hospital Research Institute
As of November 12, 2026, Find a Trial lists 211 NIH-funded research projects at this institution, with $116.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 211NIH research projects
NIH-funded research (newest 40 of 211)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Investigating how DNA damage and repair mechanisms are altered in ALS and frontotemporal dementia.
This study is looking at how problems with DNA repair might contribute to conditions like ALS and frontotemporal dementia, and it’s testing ways to fix these issues in cells from patients to help develop new treatments.
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Cefazolin Inoculum Effect and MSSA Bacteremia: A Rapid Test to Guide Therapy
A study to understand how a high bacterial load affects cefazolin treatment for serious Staphylococcus aureus infections and to test a quick lab method that helps doctors choose the best antibiotic.
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Cefazolin Inoculum Effect: How this test could improve care for MSSA bloodstream infections
This project tests a quick lab test to find a specific cefazolin resistance pattern in MSSA blood infections so doctors can choose safer, more effective treatment.
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Vascularized niche with local immune protection to transplant insulin-producing cells for Type 1 diabetes
A new approach aims to transplant insulin-producing cells inside a vascularized pocket with local drug delivery to keep them alive and functioning without full-body immune suppression.
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How brain connections guide visual choices in ADHD
A research study aims to understand how specific brain pathways help people with ADHD make visual decisions, using non-invasive methods in primates.
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Why some Klebsiella pneumoniae infections resist key carbapenem antibiotics
This project looks at why certain Klebsiella pneumoniae infections resist carbapenem antibiotics and how those infections affect adult patients.
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Targeting mitochondrial DNA repair defects in FUS-ALS with neuron-specific DNA Ligase I therapy
A patient-facing study aims to test a neuron-directed therapy that helps nerve cells repair their mitochondrial DNA in people with ALS linked to FUS mutations.
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How damaged tumor cells that survive send cell-membrane signals
This project looks at how cancer cells that suffer partial membrane damage can send signals that may encourage tumor growth.
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Alternative polyadenylation in heart fibrosis
Researchers are testing how changes in gene regulation after a gene is read (via APA) influence heart fibrosis and whether adjusting this process could help heart failure.
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Muscle-Related Enzyme TRIM55 and Autoimmune Heart Inflammation in Aicardi-Goutieres Syndrome
A new research project studies how a muscle-specific enzyme called TRIM55 drives autoimmune heart inflammation in a genetic syndrome.
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GPR6’s role in therapy resistance and antibody targeting in prostate cancer
A new project looks at how the GPR6 protein helps prostate cancer become resistant to therapy and whether antibodies against GPR6 can block this process.
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GRK3-HDAC2 epigenetic pathway in aggressive prostate cancer and immune evasion
This grant explores how a specific brain-like epigenetic switch may drive aggressive prostate cancer and help tumors hide from the immune system, with the goal of finding new ways to treat patients.
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Bladder cancer: how the tumor’s surrounding tissue shapes progression
A centralized research effort will map bladder tumors and their surrounding tissue to better understand why some cancers progress.
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Bladder cancer risk fingerprint to predict aggressive disease
A research project from a major medical center is exploring a urine-based biomarker fingerprint to identify bladder cancer at high risk of becoming more aggressive before it shows up in symptoms.
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Bladder cancer progression and risk prediction in early bladder lesions
A grant exploring how early bladder cancer progresses and which patients with non-muscle-invasive disease are most likely to worsen.
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Understanding bladder cancer growth and immune response to improve risk prediction
A study in bladder cancer patients aims to understand how early tumors progress and which patients are most likely to worsen, using insights from immune cell structures to guide future care.
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Administrative Core for a bladder cancer program
A leadership core will coordinate multiple bladder cancer research projects to keep everything organized, ethical, and on track to help patients in the long run.
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Stromal clues to bladder cancer progression
A U54 center study looks at how the bladder’s surrounding tissue shapes cancer development and uses that knowledge to identify risk markers.
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Venous ethanol ablation to treat ischemic VT (VE-VT)
A new treatment approach uses ethanol delivered through heart veins to help stop dangerous heart rhythms in patients with previous heart damage.
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ACCELERATE-PACE: Early Liver Transplantation for Alcohol-Related Liver Disease
A large study follows adults with severe alcohol-related liver disease to understand who can benefit from early liver transplantation and how best to manage care.
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Cefazolin Inoculum Effect in MSSA Bacteremia
This project tests how cefazolin works in severe MSSA bloodstream infections and whether a rapid test can predict which patients might have worse outcomes.
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Understanding brain tumor metabolism with advanced carbon tracing
This research looks at how brain tumor cells use nutrients like acetate and ketone bodies for energy, to help improve therapies for patients with gliomas and brain metastases.
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Metabolism and epigenetic changes help fibroblasts become blood vessels to repair ischemia
A new approach explores how cell metabolism and epigenetic changes help reprogram fibroblasts into endothelial cells to improve blood flow after ischemia.
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Stable mRNA vaccine for new SARS-CoV-2 variants using RNA-plex protection
A new approach aims to make mRNA vaccines against evolving COVID-19 variants more stable so they can be stored and distributed more easily.
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Non-invasive spinal stimulation to boost how the spine's sensorimotor network adapts after spinal cord injury
A doctor-led study will test two non-invasive spinal stimulation methods to help people with spinal cord injury regain standing and movement.
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Understanding How Cell States Change in Diseases Using Single-Cell Data
A scientist team will create new math tools to map how cells change their identity in tissues related to type 2 diabetes and Alzheimer's disease, using big single-cell data.
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Targeting NR4A1 and NR4A2 to boost glioblastoma treatment response
Aimed at making glioblastoma more responsive to standard therapy and immune treatment by blocking NR4A1/NR4A2 with new compounds.
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Spinal cord electrical stimulation to boost upper-body function after injury
A doctor-research team is testing a new epidural stimulation approach to help people with cervical spinal cord injuries regain arm and hand function.
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Role of lipid metabolism in CD8+ T cell ferroptosis
This research explores how fats and a deadly cell-scare called ferroptosis affect CD8+ T cells in cancer, with the goal of improving how the immune system fights tumors.
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How brain support cells help connect nerves (astrocyte matrisome and synapses)
This grant studies how human brain support cells called astrocytes influence the connections between brain cells through a complex network of extracellular proteins.
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Natural plant compounds to fight oral thrush in people with HIV
Aims to test natural plant compounds to help prevent and treat oral infections caused by Candida in people living with HIV.
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Predicting and reducing donor drop-out among racial/ethnic minority kidney donors
A study to help people from minority backgrounds who are considering living kidney donation understand and reduce the risk of dropping out during donor screening.
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Antibiotics and gut bacteria in immune-related cancer side effects
A doctor-scientist is studying how antibiotics change the gut microbiome and how these changes affect immune therapy–related gut inflammation in cancer patients.
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LiaFSR system and antimicrobial peptide resistance in enterococci
A scientist team is studying how vancomycin-resistant enterococci become resistant to powerful antibiotics, with the aim of stopping these stubborn infections.
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Sirtuin-Driven Control of TB and HIV Interactions in Macrophages
Aims to find new ways to slow or stop both tuberculosis and HIV by targeting cellular enzymes in immune cells.
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Anti-viral drugs to make chemotherapy work better for cancer patients
A cancer-focused study tests whether existing antiviral medicines can make chemotherapy more effective in solid and blood cancers.
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Sudden death risk in mitral valve prolapse using MRI and blood biomarkers
A study in people with mitral valve prolapse will look for clues in MRI scans and blood markers to identify who might be at higher risk of sudden cardiac events.
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Dual targeting of PI3K and NOS pathways in Metaplastic Breast Cancer
Aims to test a combination therapy targeting PI3K and NOS pathways to treat metaplastic breast cancer, a very rare and aggressive breast cancer type.
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IL-9–secreting Tc9 cells trigger tumor cell death to fight cancer
A new approach uses IL-9–producing Tc9 immune cells to boost the body's own ability to kill cancer cells.
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Targeted gene therapy to boost immune attack on breast cancer tumors
A new gene therapy approach uses a tumor-targeted virus to trigger cancer cell death and help the immune system attack breast cancer, including hard-to-treat metastases.
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