Role of estrogen related receptors in age-related kidney disease
Official title: Role of Estrogen Related Receptors in Age Related Kidney Disease
Funded at Georgetown University · NIH-11372132 · Data updated 2026-11-12
A study at Georgetown University is exploring whether boosting certain hormone receptors in kidneys can slow or reverse age-related kidney problems in adults 65 and older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | December 21, 2020 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $753,566 |
| NIH project number | 5R01DK127830-07 |
| Project ID | NIH-11372132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Healthy volunteers or patients with age-related kidney risk who fit the study's age criteria may be considered for future translational steps once preclinical results are established.
✕Less likely to help
The study is conducted in animal models and may not directly benefit individual patients during the initial phase.
What this research studies
This project focuses on how aging affects kidney function and whether activating estrogen related receptors (ERRs) in the kidney can prevent decline. Researchers will test effects of ERRα and ERRγ in specific kidney cells to see if they improve mitochondria, reduce harmful lipids, and lower inflammation. The work uses aging mice and aims to translate findings to older adults with kidney vulnerability, aiming to identify targeted strategies for kidney health in old age.
Why it matters
Potential benefit: If successful, the work could lead to new ways to protect kidneys from age-related decline in older adults.
How similar studies have gone: Prior studies show that activating ERRs in aging kidneys can improve some health markers in animals, suggesting potential but still early-stage results.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Levi, Moshe — Georgetown University
- Study coordinator: Levi, Moshe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.