Risk factors for alpha-gal allergy and tick bites in people with Anderson-Fabry disease
Official title: Risk factors of alpha-gal syndrome: investigating the human genetic risk factors and the tick salivary sensitizer
Funded at Kansas State University · NIH-11456513 · Data updated 2026-11-12
A research project investigates why some people, including those with Anderson-Fabry disease, develop alpha-gal allergy after a tick bite and how genetics and tick saliva contribute.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kansas State University NIH-funded |
| Lab location | 1 site (Manhattan, United States) |
| Project start | August 10, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $662,390 |
| NIH project number | 1R01AI193623-01A1 |
| Project ID | NIH-11456513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for alpha-gal syndrome, and individuals with a history of tick exposure or Anderson-Fabry disease who may be affected by AGS.
✕Less likely to help
Individuals without tick exposure or alpha-gal allergy may not benefit from this research.
What this research studies
This grant studies why certain individuals become allergic to red meat after a tick bite, focusing on human genetics and the tick’s saliva. It combines genetic analyses with examination of tick salivary components to understand who is at risk. The project uses patient samples and human data to identify genetic variants and biochemical factors that may increase susceptibility and severity of alpha-gal syndrome.
Why it matters
Potential benefit: If successful, it could lead to better risk screening and personalized precautions for people at risk of alpha-gal allergy.
How similar studies have gone: Preliminary findings have linked genetic and biochemical factors to AGS, but larger validating studies are needed.
Where this research is happening
-
Kansas State University
Manhattan, United States Active
Researchers
- Principal investigator: Park, Yoonseong — Kansas State University
- Study coordinator: Park, Yoonseong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.