Sponsor or institution
Clinical trials and research at University of South Carolina at Columbia
As of November 12, 2026, Find a Trial lists 286 NIH-funded research projects at this institution, with $151.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 286NIH research projects
NIH-funded research (newest 40 of 286)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding how altered citric acid cycle fuels may help kids and adults with Complex I mitochondrial disease
A small study will look at how changes in the citric acid cycle and a molecule called 2-HG affect people with Complex I–related mitochondrial disease, to identify potential new treatment strategies.
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Confidential social network referrals to boost HIV testing
A new approach uses anonymous mobile-text referrals to encourage people at risk to get HIV tested.
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How brain cells move and translate messages to stay healthy in Alzheimer’s and related dementias
A study to understand how RNA binding proteins affect the way brain cells transport and translate messages, which may influence Alzheimer’s and related dementias.
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Adolescent neurobehavioral outcomes after early nutrition: follow-up of a Bangladeshi trial
This project follows up on children who received nutrient-rich supplements in early life to see how it affects their brain development and behavior during adolescence.
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Adolescent neurobehavioral outcomes after early-life nutrition in a Bangladeshi cohort
This project follows up teens who were part of an early-life nutrition trial to see how their development and behavior look years later.
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Brain-boosting blood pressure pathways as a treatment to prevent and treat HAND in aging people with HIV
This research tests whether medicines that affect the brain’s blood-vessel system can protect brain cells and reduce inflammation in people aging with HIV who have cognitive problems.
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Understanding how teen social networks influence tobacco and vape use and how interventions might work
A study with high school students in the U.S., Mexico, and other countries will look at how friends and online interactions affect starting and continuing cigarette and e-cigarette use, and how different interventions could change those patterns.
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Dose guide for physical activity to improve arthritis symptoms
A study from the University of South Carolina will look at how different amounts of weekly physical activity affect arthritis symptoms and quality of life in adults with arthritis.
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Health Promotion and Cancer Prevention Network in South Carolina
A national cancer prevention network in South Carolina is testing ways to spread proven cancer prevention and control messages and practices to underserved communities.
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Bundle of nutrition, parenting, and health support to boost young children’s development
A group of researchers will test whether adding nutritious foods and responsive caregiving to health services helps children aged 6–30 months grow and develop better.
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Microglia, HIV, and cocaine: how brain circuits change
A research project will explore how HIV and cocaine history together affect brain cells and circuits that control thinking and behavior.
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Mapping chloride inside cell compartments
This project develops a new method to map chloride inside tiny parts of living cells to help people with chloride-related conditions like cystic fibrosis, certain kidney disorders, and osteoporosis.
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Using wrist-worn consumer trackers to monitor kids' activity, calorie use, and sleep (ages 5–12)
This project sees whether everyday wrist devices like Fitbits or Garmins can accurately track physical activity, calories burned, and sleep in children ages 5 to 12.
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Health Care Quality and Outcomes for Medicare Patients with Guillain-Barré Syndrome
This grant looks at how care is delivered to people with Guillain-Barré Syndrome on Medicare and how care quality affects recovery.
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Cortical Organization of Syntax in Aphasia
A patient-facing study to understand how brain injury affects sentence structure and help people with aphasia communicate more clearly.
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Estimating How Much Time Kids Spend on Mobile Screens
A study to develop reliable ways to measure how much time a child actually spends on smartphones, tablets, and wearables, using built-in device data.
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A Sleep program for preschoolers by guiding their parents
A parent-delivered, prevention-focused sleep program for preschoolers aged 2–4 to help kids sleep better and support family wellbeing.
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Digital biomarkers from wearables for cardiovascular health
A researcher will develop new ways to read and combine data from wearable sensors (like heart rate, activity, and glucose monitors) to better understand heart and brain health in people.
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Optimizing lifestyle programs to improve health in African Americans and rural communities
A nationwide project will analyze how different lifestyle change programs (like diet and exercise) work best for Black communities and rural residents to reduce chronic diseases over time.
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Community-based effort to boost physical activity in older African American adults through church programs
A community-driven project in churches aims to help older African American adults become more physically active using a proven program and local partnerships.
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Health Research Core supports translational pilots in Midlands SC
A Core at the University of South Carolina helps fund and guide early-stage clinical and translational projects to improve health in the Midlands of South Carolina.
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RDCD: A core to improve how we design and run clinical research
A university-based program provides training, design help, and data management support to ensure clinical studies are rigorous, ethical, and well-powered within a patient-focused research network.
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Clinical Engagement & Outreach Core connects communities to clinical research in South Carolina
A center-led effort to create a network of clinics in the South Carolina Midlands that can support patient-facing clinical and translational research, especially for vulnerable populations.
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Professional Development Core helps researchers secure and grow clinical/translational projects
A dedicated program at USC trains and mentors researchers to obtain external funding and build collaborative clinical/translational studies.
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Administrative Core supports building a strong clinical & translational research program
This grant funds an Administrative Core to help a regional center do patient-focused clinical research on diabetes, heart disease, cancer, and other illnesses.
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Center for Translational Research at USC: advancing care for chronic diseases in South Carolina
A major center at the University of South Carolina is creating a stronger, more connected team to move clinical insights into real-world care for chronic diseases that affect people in the Midlands.
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FXTAS in Women with the FMR1 Premutation: Understanding Symptoms Across Adult Life
This grant studies how FXTAS affects women with the FMR1 premutation over time to help doctors forecast problems and support patients.
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Social communication patterns in young children with the FMR1 premutation
This grant studies how social communication changes in young children who carry the FMR1 premutation and how these changes relate to anxiety and autism-like symptoms.
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Administrative Core supports a center studying FMR1 premutation disorders across life
A funding center is coordinating research to understand FXTAS and FXAND across the lifespan to help people with the FMR1 premutation.
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FMR1 Premutation Across the Lifespan: Understanding how FXTAS and FXAND develop over time
This NIH grant supports a multi-year effort to understand how FMR1 premutation-related conditions like FXTAS and FXAND unfold from early childhood through adulthood, so doctors can predict risk and guide care.
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Center-based childcare to curb excess weight gain in preschoolers from low-income families during summer
A summer program using center-based childcare to help preschoolers from low-income households gain and maintain healthier weights.
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Cancer survival in colon and lung cancer: how new therapies and access to care affect outcomes
This grant links state cancer data, insurance claims, and mental health records to study how younger cancer patients use new targeted therapies and what factors influence their survival.
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Bundle of nutrition, parenting and healthy routines to boost early childhood development
A funded program will test how combining responsive parenting, nutrition (eggs and dried fish), and infection-control activities affects young children's development in Liberia.
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Understanding anxiety in Fragile X syndrome across childhood
A study follows children and young people with Fragile X syndrome to understand how anxiety starts, stays, and what predicts it over time.
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tDCS plus speech therapy to improve language in people with aphasia
A large, patient-facing study will test whether adding transcranial direct current stimulation to speech therapy helps people with aphasia after a stroke communicate better.
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Brain aging and aphasia after stroke
We’re learning how aging affects language problems after a stroke and how brain aging markers might help predict and improve care for people with aphasia.
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ADRD training program to grow leaders in public health aging research
Aims to train 12 junior scholars in how non-medical factors like housing and neighborhood conditions affect Alzheimer’s and related dementias, helping build a stronger public health research workforce.
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Helping babies get timely well-child visits with community health workers and phone-based support
This project uses community health workers, phone reminders, small incentives, and smart computer alerts to help caregivers bring babies under one year to on-time well-child visits.
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Micellar drug carriers: a new modeling platform for better cancer therapies
Researchers will build a computer-based platform to predict how micellar drug carriers behave in the body, helping tailor cancer treatments.
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Confidential SMS referrals to encourage HIV testing for high-risk people
A new program uses anonymous text message referrals to help people at higher risk for HIV get tested.
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