Reducing chronic leg problems after blood clots
Official title: Preventing Post-Thrombotic Syndrome after Deep Vein Thrombosis with Perivascular Anti-Inflammatory Agent Delivery
Funded at Mercator Medsystems, INC. · NIH-10823041 · Data updated 2026-11-12
This study is looking at a new way to help people who have had a blood clot (DVT) avoid developing a painful condition called post-thrombotic syndrome (PTS) by using special treatments that reduce inflammation in the affected blood vessels, so you can feel better and improve your quality of life.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mercator Medsystems, INC. NIH-funded |
| Lab location | 1 site (San Leandro, UNITED STATES) |
| Project start | September 20, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,636,379 |
| NIH project number | 2R44HL160434-02 |
| Project ID | NIH-10823041 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with deep vein thrombosis and are at risk of developing post-thrombotic syndrome.
✕Less likely to help
Patients who have not experienced deep vein thrombosis or those with other unrelated chronic conditions may not benefit from this research.
What this research studies
This research focuses on preventing post-thrombotic syndrome (PTS), a painful and debilitating condition that can occur after deep vein thrombosis (DVT). The approach involves delivering anti-inflammatory agents directly to the affected blood vessels to address the underlying inflammation that contributes to PTS. By targeting the inflammation rather than just the blood clot itself, the research aims to improve patient outcomes and quality of life. Patients will be monitored for changes in symptoms and overall health as part of the treatment process.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of post-thrombotic syndrome in patients who have experienced deep vein thrombosis.
How similar studies have gone: While catheter-based therapies have been tested, this approach of directly targeting inflammation with anti-inflammatory agents is novel and has not been extensively studied.
Where this research is happening
-
Mercator Medsystems, INC.
San Leandro, United States Active
Researchers
- Principal investigator: Seward, Kirk — Mercator Medsystems, INC.
- Study coordinator: Seward, Kirk
Related research
Other NIH-funded projects on the same topics.
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Understanding how DVT forms and heals to prevent vein scarring
This NIH grant supports a physician-scientist to study why deep vein clots form and how vein walls get scarred, with the goal of improving long-term outcomes for patients who develop DVT.
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Oscillatory blood flow and vein valve health to prevent clots
Aimed at understanding how the natural rhythmic blood flow in leg veins protects against clots and whether restoring that flow can prevent dangerous vein clots in hospitalized patients.
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Local anti-inflammatory therapy to help dissolve clots and prevent vein damage in DVT
Aims to test a local anti-inflammatory treatment to help resolve deep vein clots and reduce long-term vein problems in people with DVT.
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Neutrophil integrin α9 and blood clots after stroke in aging
This project looks at how a molecule on white blood cells called neutrophil integrin α9 might cause dangerous vein clots after a stroke, especially in older adults.
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Metabolic tricks to prevent and heal dangerous blood clots in the leg
A study at a university aims to see if shifting how certain blood cells use energy can stop leg clots from forming and help bodies clear clots faster, reducing future complications.
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Stopping long-term leg damage after deep vein clots by giving anti-inflammatory medicine around the vein
This will try giving anti-inflammatory medicine around the affected vein to lower the chance of long-term swelling, pain, and skin problems after a deep vein clot (DVT).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.