Race-specific heart risk tools for African American childhood cancer survivors
Official title: Developing and validating race-specific cardiomyopathy risk prediction models in African American survivors of childhood cancer
Funded at St. Jude Children's Research Hospital · NIH-11326331 · Data updated 2026-11-12
Aims to create and validate heart-disease risk models specifically for African American survivors of childhood cancer who were treated with heart-damaging therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | May 15, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $737,231 |
| NIH project number | 5R01HL173881-03 |
| Project ID | NIH-11326331 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are African American survivors of childhood cancer who received anthracycline chemotherapy or chest-directed radiation and have long-term follow-up data.
✕Less likely to help
Patients without long-term follow-up data or who are not African American may not benefit from these race-specific models.
What this research studies
This project uses data from St. Jude’s long-term survivor cohort to find the most important predictors of developing cardiomyopathy and then builds risk prediction models tailored to African American survivors. It will train and validate these models using up to 700 AA participants with detailed clinical information and follow-up. The goal is to improve early identification of those at highest risk so clinicians can tailor monitoring and preventive strategies. The study emphasizes race-specific insights to address a disproportionate burden of cardiac disease in this population.
Why it matters
Potential benefit: If successful, the models could help doctors personalize heart monitoring and prevention for AA survivors, potentially reducing heart failure risk.
How similar studies have gone: Previous general cardiomyopathy risk models exist but race-specific tools for AA childhood cancer survivors are not yet established.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Sapkota, Yadav — St. Jude Children's Research Hospital
- Study coordinator: Sapkota, Yadav
Related research
Other NIH-funded projects on the same topics.
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Using ECG and AI to find childhood cancer survivors at risk for late cardiomyopathy
This project uses routine ECG tracings plus artificial intelligence to spot childhood cancer survivors who may develop heart muscle disease years later.
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Creating heart disease risk models for African American childhood cancer survivors
This study is looking to find out how to better predict heart problems in African American childhood cancer survivors who received certain treatments, so they can catch any issues early and help keep their hearts healthy.
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Identifying childhood cancer survivors at risk for heart problems using AI and ECG data.
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Using machine learning to identify heart disease risk in childhood cancer survivors
This study is looking at how smart computer programs can help doctors find heart problems earlier in childhood cancer survivors who have had certain treatments, so they can get better care and stay healthier.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.